Retinal Degenerative Diseases

Mechanisms and Experimental Therapy

ISBN: 978-1-4614-3208-1 (Print) 978-1-4614-3209-8 (Online)

Table of contents (106 chapters)

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  1. Front Matter

    Pages i-lxi

  2. Basic Processes: Development, Physiology and Function

    1. Front Matter

      Pages 1-1

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      Pages 3-8

      Cell Type-Specific Epigenetic Signatures Accompany Late Stages of Mouse Retina Development

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      Pages 9-13

      Programmed Cell Death During Retinal Development of the Mouse Eye

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      Pages 15-21

      Spatial and Temporal Localization of Caveolin-1 Protein in the Developing Retina

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      Pages 23-30

      Glutathione S-Transferase Pi Isoform (GSTP1) Expression in Murine Retina Increases with Developmental Maturity

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      Pages 31-41

      RETINA-Specific Expression of Kcnv2 Is Controlled by Cone-Rod Homeobox (Crx) and Neural Retina Leucine Zipper (Nrl)

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      Pages 43-48

      AIPL1 Protein and its Indispensable Role in Cone Photoreceptor Function and Survival

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      Pages 49-56

      Primate Short-Wavelength Cones Share Molecular Markers with Rods

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      Pages 57-65

      Exploration of Cone Cyclic Nucleotide-Gated Channel-Interacting Proteins Using Affinity Purification and Mass Spectrometry

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      Pages 67-73

      Electrophysiological Characterization of Rod and Cone Responses in the Baboon Nonhuman Primate Model

  3. Basic Processes: RPE

    1. Front Matter

      Pages 75-75

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      Pages 77-83

      Animal Models, in “The Quest to Decipher RPE Phagocytosis

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      Pages 85-90

      In Vivo and in Vitro Monitoring of Phagosome Maturation in Retinal Pigment Epithelium Cells

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      Pages 91-96

      Lack of Effect of Microfilament or Microtubule Cytoskeleton-Disrupting Agents on Restriction of Externalized Phosphatidylserine to Rod Photoreceptor Outer Segment Tips

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      Pages 97-103

      Vacuolar ATPases and Their Role in Vision

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      Pages 105-111

      Rescue of Compromised Lysosomes Enhances Degradation of Photoreceptor Outer Segments and Reduces Lipofuscin-Like Autofluorescence in Retinal Pigmented Epithelial Cells

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      Pages 113-119

      The Role of Bestrophin-1 in Intracellular Ca2+ Signaling

  4. Basic Processes: Methodology

    1. Front Matter

      Pages 121-121

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      Pages 123-129

      Application of Next-Generation Sequencing to Identify Genes and Mutations Causing Autosomal Dominant Retinitis Pigmentosa (adRP)

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      Pages 131-137

      Digital Quantification of Goldmann Visual Fields (GVFs) as a Means for Genotype–Phenotype Comparisons and Detection of Progression in Retinal Degenerations

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      Pages 139-143

      Simplified System to Investigate Alteration of Retinal Neurons in Diabetes

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      Pages 145-154

      What is the Nature of the RGC-5 Cell Line?

  5. Genetics in Retinal Disease

    1. Front Matter

      Pages 155-155

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      Book Chapter

      Pages 157-164

      Modeling Retinal Dystrophies Using Patient-Derived Induced Pluripotent Stem Cells

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