2012

Novel Developments in Stem Cell Mobilization

Focus on CXCR4

Editors:

ISBN: 978-1-4614-1959-4 (Print) 978-1-4614-1960-0 (Online)

Table of contents (24 chapters)

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  1. Front Matter

    Pages i-xiv

  2. Basic Science and Experimental Studies on Stem Cell Mobilization

    1. Front Matter

      Pages 1-1

    2. No Access

      Book Chapter

      Pages 3-22

      Preclinical Experience with AMD3100 for Mobilization of Hematopoietic Stem and Progenitor Cells

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      Book Chapter

      Pages 23-35

      Molecular Pharmacology of CXCR4 Inhibition

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      Book Chapter

      Pages 37-54

      Combination Strategies for Stem Cell Mobilization Targeting CXCR4 and S1P Receptors

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      Book Chapter

      Pages 55-69

      Should We Stay or Should We Go Now?

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      Book Chapter

      Pages 71-85

      Role of the CXCR4/CXCL12 Axis in Hematopoietic Stem Cell Trafficking

  3. Clinical Studies on Stem Cell Mobilization

    1. Front Matter

      Pages 87-87

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      Book Chapter

      Pages 89-101

      Early Studies of AMD3100/Plerixafor in Healthy Volunteers

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      Book Chapter

      Pages 103-131

      The Current Role of Plerixafor in Stem Cell Mobilization for Hematopoietic Stem Cell Transplantation

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      Book Chapter

      Pages 133-163

      Experience with Apheresis Procedures After Plerixafor Mobilisation

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      Book Chapter

      Pages 165-200

      Influence of Different Stem Cell Mobilization Strategies on Graft Composition and Outcome of Autologous or Allogeneic Transplantation

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      Book Chapter

      Pages 201-219

      Relevance and Clinical Implications of Tumor Cell Mobilization in Autologous Transplantation of Multiple Myeloma and Non-Hodgkin’s Lymphoma

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      Book Chapter

      Pages 221-234

      Plerixafor: Data from the Compassionate Use Program

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      Book Chapter

      Pages 235-246

      Stem Cell Mobilization with Chemomobilization Plus Plerixafor in Hard-to-Mobilize Patients: The Experience at Kuopio University Hospital, Finland

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      Book Chapter

      Pages 247-262

      Blood Stem Cell Mobilization in Solid Tumors: Experience with Plerixafor and Alternative Ways of Hematopoietic Stem Cell Mobilization

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      Book Chapter

      Pages 263-276

      Mobilization with Chemotherapy + G-CSF + Plerixafor in Europe: The Italian Experience

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      Book Chapter

      Pages 277-301

      Experience with Plerixafor in Poor Mobilizers

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      Book Chapter

      Pages 303-332

      CXCR4 Antagonists

  4. CXCR4 Antagonists for Treatment of Leukemias and Solid Tumors

    1. Front Matter

      Pages 333-333

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      Book Chapter

      Pages 335-349

      Application of CXCR4 Inhibitors in Leukemia

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      Book Chapter

      Pages 351-367

      CXCR4 Antagonists for the Treatment of CML

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      Book Chapter

      Pages 369-385

      Targeting CXCR4 in Chronic Lymphocytic Leukemia: Preclinical Rationale and Early Clinical Experience

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      Book Chapter

      Pages 387-397

      CXCR4-Blockade for Treatment of Breast Cancer

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