Systems Biology of Tumor Dormancy


ISBN: 978-1-4614-1444-5 (Print) 978-1-4614-1445-2 (Online)

Table of contents (12 chapters)

  1. Front Matter

    Pages i-xviii

  2. Angiogenesis

    1. Front Matter

      Pages 1-1

    2. Chapter

      Pages 3-17

      Genes and Regulatory Pathways Involved in Persistence of Dormant Micro-tumors

    3. Chapter

      Pages 19-35

      The Host Support Niche as a Control Point for Tumor Dormancy: Implications for Tumor Development and Beyond

    4. Chapter

      Pages 37-52

      Insights into the Regulation of Tumor Dormancy by Angiogenesis in Experimental Tumors

  3. Stem Cells and Signaling Pathways

    1. Front Matter

      Pages 53-53

    2. Chapter

      Pages 55-71

      Cancer Stem Cells and Tumor Dormancy

    3. Chapter

      Pages 73-89

      Regulation of Tumor Cell Dormancy by Tissue Microenvironments and Autophagy

    4. Chapter

      Pages 91-107

      Tumor Dormancy, Oncogene Addiction, Cellular Senescence, and Self-Renewal Programs

  4. Immune System

    1. Front Matter

      Pages 109-109

    2. Chapter

      Pages 111-143

      Multifaceted Kinetics of Immuno-Evasion from Tumor Dormancy

    3. Chapter

      Pages 145-179

      Tumor Dormancy and Cancer Stem Cells: Two Sides of the Same Coin?

    4. Chapter

      Pages 181-200

      Tumor Dormancy: Long-Term Survival in a Hostile Environment

    5. Chapter

      Pages 201-234

      A Review of Mathematical Models of Cancer–Immune Interactions in the Context of Tumor Dormancy

  5. Mathematical Biosciences and Dynamical Systems Modeling

    1. Front Matter

      Pages 235-235

    2. Chapter

      Pages 237-259

      Regulation of Tumor Dormancy and Role of Microenvironment: A Mathematical Model

    3. Chapter

      Pages 261-282

      Seeing the Invisible: How Mathematical Models Uncover Tumor Dormancy, Reconstruct the Natural History of Cancer, and Assess the Effects of Treatment

  6. Back Matter

    Pages 283-291