2012

Antibiotic Discovery and Development

Editors:

ISBN: 978-1-4614-1399-8 (Print) 978-1-4614-1400-1 (Online)

Table of contents (37 chapters)

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  1. Front Matter

    Pages i-xvii

  2. Introductory History of Antimicrobial Drugs

    1. Front Matter

      Pages 1-1

    2. No Access

      Book Chapter

      Pages 3-31

      The Early History of Antibiotic Discovery: Empiricism Ruled

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      Book Chapter

      Pages 33-75

      Rational Approaches to Antibacterial Discovery: Pre-Genomic Directed and Phenotypic Screening

  3. Marketed Major Classes of Compounds

    1. Front Matter

      Pages 77-77

    2. No Access

      Book Chapter

      Pages 79-117

      Beta-Lactam Antibiotics

    3. No Access

      Book Chapter

      Pages 119-146

      Review of the Quinolone Family

    4. No Access

      Book Chapter

      Pages 147-179

      Tetracyclines

    5. No Access

      Book Chapter

      Pages 181-228

      Macrolides and Ketolides

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      Book Chapter

      Pages 229-269

      Aminoglycosides

    7. No Access

      Book Chapter

      Pages 271-299

      Oxazolidinone Antibacterial Agents

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      Book Chapter

      Pages 301-346

      Glycopeptides and Lipoglycopeptides

  4. The Rise of Antibiotic Resistance/Resistance Mechanisms to Major Classes

    1. Front Matter

      Pages 347-347

    2. No Access

      Book Chapter

      Pages 349-395

      Efflux-Mediated Antimicrobial Resistance

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      Book Chapter

      Pages 397-425

      Structural Mechanisms of β-Lactam Antibiotic Resistance in Penicillin-Binding Proteins

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      Book Chapter

      Pages 427-453

      Evolution of β-Lactamases: Past, Present, and Future

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      Book Chapter

      Pages 455-484

      Inducible Resistance to Macrolide Antibiotics

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      Book Chapter

      Pages 485-514

      Fluoroquinolone Resistance: Mechanisms, Restrictive Dosing, and Anti-Mutant Screening Strategies for New Compounds

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      Book Chapter

      Pages 515-542

      Glycopeptide Resistance

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      Book Chapter

      Pages 543-568

      Acquired Tetracycline Resistance Genes

  5. Clinical Issues of Resistance: “Worst Offenders” List of Problematic Microbes Gram-positives

    1. Front Matter

      Pages 569-569

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      Book Chapter

      Pages 571-592

      Evolution of Molecular Techniques for the Characterization of MRSA Clones

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      Book Chapter

      Pages 593-616

      Mechanisms of Penicillin Resistance in Streptococcus pneumoniae: Targets, Gene Transfer and Mutations

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      Book Chapter

      Pages 617-648

      Clinical Aspects of Multi-Drug Resistant Enterococci

  6. Gram-negatives

    1. Front Matter

      Pages 649-649

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      Book Chapter

      Pages 651-678

      Clinical Issues of Resistance: Problematic Microbes: Enterobacteriaceae

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