Retinal Degenerative Diseases

ISBN: 978-1-4614-0630-3 (Print) 978-1-4614-0631-0 (Online)

Table of contents (108 chapters)

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  1. Front Matter

    Pages i-lxiv

  2. AMD: Basic Mechanisms, Inflammation and Immunity

    1. Front Matter

      Pages 1-1

    2. Chapter

      Pages 3-9

      A Window to Innate Neuroimmunity: Toll-Like Receptor-Mediated Cell Responses in the Retina

    3. Chapter

      Pages 11-16

      Autoimmune Biomarkers in Age-Related Macular Degeneration: A Possible Role Player in Disease Development and Progression

    4. Chapter

      Pages 17-22

      Local Vs. Systemic Mononuclear Phagocytes in Age-Related Macular Degeneration and Their Regulation by CCL2–CCR2 and CX3CL1–CX3CR1 Chemokine Signalling

    5. Chapter

      Pages 23-30

      Sublytic Membrane-Attack-Complex Activation and VEGF Secretion in Retinal Pigment Epithelial Cells

    6. Chapter

      Pages 31-36

      Complement Activation in Retinal Degeneration

    7. Chapter

      Pages 37-42

      Microglia in the Outer Retina and Their Relevance to Pathogenesis of Age-Related Macular Degeneration

    8. Chapter

      Pages 43-50

      Lutein or Zeaxanthin Supplementation Suppresses Inflammatory Responses in Retinal Pigment Epithelial Cells and Macrophages

    9. Chapter

      Pages 51-59

      Exploring the Potential Role of the Oxidant-Activated Transcription Factor Aryl Hydrocarbon Receptor in the Pathogenesis of AMD

    10. Chapter

      Pages 61-66

      Common Mechanisms for Separate Maculopathies?

    11. Chapter

      Pages 67-74

      The Role of Amyloid-β in Retinal Degeneration

    12. Chapter

      Pages 75-81

      Molecule-Specific Imaging and Quantitation of A2E in the RPE

    13. Chapter

      Pages 83-90

      Autophagy in the Retina: A Potential Role in Age-Related Macular Degeneration

  3. Neuroprotection, Drugs and Novel Protective Therapies

    1. Front Matter

      Pages 91-91

    2. Chapter

      Pages 93-99

      Regeneration of Cone Outer Segments Induced by CNTF

    3. Chapter

      Pages 101-106

      Glucocorticoid-Dependent Mechanisms in Photoreceptor Survival

    4. Chapter

      Pages 107-113

      HDAC Inhibition Prevents Rd1 Mouse Photoreceptor Degeneration

    5. Chapter

      Pages 115-120

      Neuroprotective Dose Response in RCS Rats Implanted with Microphotodiode Arrays

    6. Chapter

      Pages 121-128

      Treatment with 670-nm Light Protects the Cone Photoreceptors from White Light-Induced Degeneration

    7. Chapter

      Pages 129-136

      Dark-Rearing the rd10 Mouse: Implications for Therapy

    8. Chapter

      Pages 137-143

      Intravitreal Injection of Erythropoietin Glycosylation Analogs Does Not Protect Rod Photoreceptor Cells from Light-Induced Damage

    9. Chapter

      Pages 145-153

      Relieving Bottlenecks in RNA Drug Discovery for Retinal Diseases

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