Insulin-like Growth Factors and Cancer

From Basic Biology to Therapeutics


ISBN: 978-1-4614-0597-9 (Print) 978-1-4614-0598-6 (Online)

Table of contents (14 chapters)

  1. Front Matter

    Pages i-xii

  2. Chapter

    Pages 1-24

    Epidemiology of IGF-1 and Cancer

  3. Chapter

    Pages 25-36

    Aging and Cancer: The IGF-I Connection

  4. Chapter

    Pages 37-72

    Obesity, Type 2 Diabetes and Cancer

  5. Chapter

    Pages 73-84

    IGF System and Breast Cancer

  6. Chapter

    Pages 85-103

    The Role of Insulin-Like Growth Factor Signaling in Prostate Cancer Development and Progression

  7. Chapter

    Pages 105-146

    IGF-1 Cellular Action and its Relationship to Cancer: Evidence from in Vitro and in Vivo Studies

  8. Chapter

    Pages 147-158

    Insulin-Like Growth Factor Signaling in Pediatric Sarcomas

  9. Chapter

    Pages 159-177

    Cancer Genes, Tumor Suppressors, and Regulation of IGF1-R Gene Expression in Cancer

  10. Chapter

    Pages 179-191

    Mouse Models of IGF-1R and Cancer

  11. Chapter

    Pages 193-213

    Targeting the Insulin-Like Growth Factor-I Receptor in Cancer Therapy

  12. Chapter

    Pages 215-229

    Targeting Insulin-Like Growth Factor Receptor 1 (IGF-1R) and Insulin Receptor Signaling by Tyrosine Kinase Inhibitors in Cancer

  13. Chapter

    Pages 231-243

    Calories and Cancer: The Role of Insulin-Like Growth Factor-1

  14. Chapter

    Pages 245-261

    Cancer Cell Metabolism

  15. Chapter

    Pages 263-278

    Overlaps Between the Insulin and IGF-I Receptor and Cancer

  16. Back Matter

    Pages 279-284