The Testis

1. Epididymal Maturation and Fertilization

   1. Regulation of Epididymal Function by Testicular Factors: The Lumicrine Hypothesis

      • Barry T. Hinton, Zi Jian Lan, R. John Lye, Jacquelyn C. Labus

      Pages 163-173

   2. Aging Causes Structural and Functional Alterations in the Epididymis

      • Bernard Robaire, Valerie Serre

      Pages 174-185

   3. The Molecular Basis of Speim—Egg Interactions

      • David L. Garbers, Timothy A. Quill

      Pages 186-197

2. Genetic Defects and Remedies

   1. Front Matter

      Pages 199-199

      PDF

   2. Heritable Sperm Degeneration in the Domestic Fowl

      • John D. Kirby, David P. Froman, Douglas D. Rhoads

      Pages 201-212

   3. The DAZ Gene Family and Germ-Cell Development

      • Renee A. Reijo Pera

      Pages 213-225

   4. Genetic Defects of Male Infertility and ICSI

      • Jan A. M. Kremer, Joep H. A. M. Tuerlings, Ron van Golde, Eric J. H. Meuleman, Didi D. M. Braat

      Pages 226-232

   5. Spermatids: Clinically Useful Gametes?

      • Fay L. Shamanski, Paul J. Turek, Roger A. Pedersen

      Pages 233-244

   6. Effect of Embryo Culture on Imprinted Gene Expression in the Preimplantation Mouse Embryo

      • Richard M. Schultz, Kimberly D. Tremblay, Adam S. Doherty, Marisa S. Bartolomei

      Pages 245-255

3. Back Matter

   Pages 257-265

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This volume contains the proceedings of the XVth North American Testis Workshop, held in Louisville, Kentucky, April 7 to 10, 1999, to describe current advances in testis biology. The first two chapters provide a useful historical perspective of testis physiology and formulate compelling research questions about important aspects of sperm formation and function. This prologue sets the scene for the remainder of the volume that follows a logical progression, as the title implies, from stem cell to cell function, but that is necessarily preceded by sex determination, the quintessential requirement for there being a testis in the first place. The program for this XVth Testis Workshop evolved from recommenda­ tions of the scientific committee and their advice on the selection of invited speakers. The XVth Testis Workshop has a strong comparative flavor with contributions on worms (Caenorhabditis), flies (Drosophila), and chickens, which are models that permit and thereby reveal the power of genetic analy­ ses of the molecular mechanisms involved in spermatogenesis. A glimpse into the future is provided with information from EST, protein, and genome databases that already have an impact on progress in our understanding of the male germ cell. Although there is heavy emphasis in these chapters on cellular and molecular e,¥ents, database mining and translational profiling relevant to testis function and dysfunction and assisted reproduction tech­ nologies are not overlooked.

• aging
• biology
• cell biology
• chaperone
• development
• fertility
• gene expression
• genes
• genetics
• infertility
• protein
• stem cell
• testis
• therapy

• Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, USA

  Erwin Goldberg

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