BeadChip Molecular Immunohematology

Toward Routine Donor and Patient Antigen Profiling by DNA Analysis

  • Paul M. Ness
  • Steve R. Sloan
  • JoAnn M. Moulds
Conference proceedings

DOI: 10.1007/978-1-4419-7512-6

Table of contents

  1. Front Matter
    Pages i-xxii
  2. JoAnn M. Moulds, Steven R. Sloan
    Pages 9-16
  3. Sandrine Kappler-Gratias, Thierry Peyrard, Pierre-Yves Le Pennec, Jean-Pierre Cartron, Philippe Rouger, Bach-Nga Pham
    Pages 83-86
  4. Nicoletta Revelli, Cinzia Paccapelo, Paola Ponzo, Francesca Truglio, Veronica Sala, Francesca Poli et al.
    Pages 87-92
  5. Marion E. Reid, Christine Halter Hipsky
    Pages 101-120
  6. Kairali Podual, Yi Zhang, Natalia Mezokh, Jiacheng Yang, Randall Wilson
    Pages 133-148
  7. Back Matter
    Pages 149-152

About these proceedings

Introduction

We have entered the era of molecular immunohematology in which DNA is analyzed to predict red blood cell and platelet phenotypes. Indeed, many laboratories and blood banks across the world have already adopted and implemented molecular techniques. Some fear that serology is now becoming outdated, but immunohematology techniques often supplement the work of serologists, and several leading serology laboratories are the very same ones that were early adopters of molecular immunohematology. This book is a thorough review of molecular immunohematology and is aimed at anyone interested in how it is changing blood bank and transfusion medicine. BeadChip Molecular Immunohematology opens with a history of serology before it provides an overview of gene expression, how genetic variations translate into antigenic differences on the surfaces of cells, and techniques that have been developed to detect genetic variations. It then describes in detail the BeadChip technology developed by BioArray Solutions, the molecular immunohematology system that has been most widely adopted in blood blank laboratories. The remainder of the book focuses on analyses and case studies from around the world to describe how molecular immunohematology is being used in various settings for various purposes. It includes a discussion of the significant advances that have been made to incorporate Rh testing on the BeadChip platform as well as the potential use of that system.

Editors and affiliations

  • Paul M. Ness
    • 1
  • Steve R. Sloan
    • 2
  • JoAnn M. Moulds
    • 3
  1. 1.Transfusion Medicine Div.Johns Hopkins HospitalBaltimoreUSA
  2. 2.Pediatric Transfusion MedicineChildren's Hospital BostonBostonUSA
  3. 3.Scientific Support ServicesLifeShare Blood CentersShreveportUSA

Bibliographic information

  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4419-7511-9
  • Online ISBN 978-1-4419-7512-6