2011

Folding for the Synapse

Editors:

ISBN: 978-1-4419-7060-2 (Print) 978-1-4419-7061-9 (Online)

Table of contents (15 chapters)

  1. Front Matter

    Pages i-viii

  2. Folding for the Synapse

    1. Front Matter

      Pages 7-7

    2. No Access

      Book Chapter

      Pages 1-6

      Folding for the Synapse

  3. The regulation of protein (mis)folding, aggregation and degradation of proteins by molecular chaperones

    1. Front Matter

      Pages 7-7

    2. No Access

      Book Chapter

      Pages 9-34

      Protein Aggregation: Opposing Effects of Chaperones and Crowding

    3. No Access

      Book Chapter

      Pages 35-48

      Molecular Chaperones as Facilitators of Protein Degradation

    4. No Access

      Book Chapter

      Pages 49-77

      The Small Heat-Shock Proteins: Cellular Functions and Mutations Causing Neurodegeneration

  4. The Making of the Synapse: Transport of Proteins, Vesicles and Organelles

    1. Front Matter

      Pages 79-79

    2. No Access

      Book Chapter

      Pages 81-103

      Keeping it Together. Axonal Transport to the Synapse and the Effects of Molecular Chaperones in Health and Disease

    3. No Access

      Book Chapter

      Pages 105-119

      Mechanisms of Neuronal Mitochondrial Transport

  5. Chaperone modalities and homeostatic mechanisms in the synaptic compartment

    1. Front Matter

      Pages 121-121

    2. No Access

      Book Chapter

      Pages 123-144

      Molecular Chaperones in the Mammalian Brain: Regional Distribution, Cellular Compartmentalization and Synaptic Interactions

    3. No Access

      Book Chapter

      Pages 145-176

      Cysteine-String Protein’s Role at Synapses

    4. No Access

      Book Chapter

      Pages 177-199

      The Role of Protein SUMOylation in Neuronal Function

    5. No Access

      Book Chapter

      Pages 201-212

      The Ubiquitin–Proteasome System in Synapses

  6. Chronic neurodegeneration associated with protein misfolding and synaptic dysfunction

    1. Front Matter

      Pages 213-213

    2. No Access

      Book Chapter

      Pages 215-231

      VAPB Aggregates and Neurodegeneration

    3. No Access

      Book Chapter

      Pages 233-255

      Synaptic Dysfunction in Huntington’s Disease

    4. No Access

      Book Chapter

      Pages 257-267

      Synaptic Dysfunction in Parkinson’s Disease: From Protein Misfolding to Functional Alterations

    5. No Access

      Book Chapter

      Pages 269-287

      Synapses and Alzheimers’s Disease: Effect of Immunotherapy?

    6. No Access

      Book Chapter

      Pages 289-312

      Prion Protein Misfolding at the Synapse

  7. Back Matter

    Pages 313-318