Advances in TNF Family Research

Proceedings of the 12th International TNF Conference, 2009

Editors:

ISBN: 978-1-4419-6611-7 (Print) 978-1-4419-6612-4 (Online)

Table of contents (66 chapters)

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  1. Front Matter

    Pages i-xxxvi

  2. Roles of the TNF Family in Tissue Homeostasis and Normal Development

    1. Front Matter

      Pages 1-1

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      Pages 3-4

      Workshop Summary: Roles of the TNF Family in Normal Development and Cancer

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      Book Chapter

      Pages 5-22

      TNF Conference 2009: Beyond Bones – RANKL/RANK in the Immune System

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      Pages 23-33

      The Edar Subfamily in Hair and Exocrine Gland Development

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      Pages 35-44

      High Endothelial Venule Reporter Mice to Probe Regulation of Lymph Node Vasculature

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      Pages 45-50

      Eiger and Wengen: The Drosophila Orthologs of TNF/TNFR

  3. Novel Aspects of Signaling Activation by the TNF Family: Novel Aspects of the Functions of the TRAFs and cIAPs

    1. Front Matter

      Pages 51-51

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      Book Chapter

      Pages 53-61

      Workshop Summary: Novel Aspects of the Functions of the TRAFs and cIAPs

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      Book Chapter

      Pages 63-78

      TRAF2 and Cellular IAPs: A Critical Link in TNFR Family Signaling

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      Pages 79-88

      New Perspectives in TNF-R1-Induced NF-κB Signaling

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      Pages 89-91

      Structural Studies of NEMO and TRAF6: Implications in NF-κB Activation

  4. Novel Aspects of Signaling Activation by the TNF : Ubiquitin-Modification of Signaling Proteins

    1. Front Matter

      Pages 93-93

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      Book Chapter

      Pages 95-106

      Modification by Single Ubiquitin Moieties Rather Than Polyubiquitination Is Sufficient for Proteasomal Processing of the p105 NF-κB Precursor

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      Pages 107-114

      Selective Binding of Linear Ubiquitin Chains to NEMO in NF-kappaB Activation

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      Pages 115-126

      The Linear Ubiquitin Chain Assembly Complex (LUBAC) Forms Part of the TNF-R1 Signalling Complex and Is Required for Effective TNF-Induced Gene Induction and Prevents TNF-Induced Apoptosis

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      Pages 127-128

      Temporal Control of TNFα Signaling by Miz1

  5. Novel aspects of Signaling Activation by the TNF Family: TNF Signaling- and gene Regulatory-Networks

    1. Front Matter

      Pages 129-129

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      Book Chapter

      Pages 131-139

      Large-Scale RNAi Screens to Dissect TNF and NF-κB Signaling Pathways

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      Book Chapter

      Pages 141-150

      Pathogenic Role of IL-6 Combined with TNF-α or IL-1 in the Induction of Acute Phase Proteins SAA and CRP in Chronic Inflammatory Diseases

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      Book Chapter

      Pages 151-161

      Understanding Life and Death at CD95

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      Pages 163-167

      Unique Personalities Within the NF-κB Family: Distinct Functions for p65 and RelB in the Osteoclast

  6. Roles of the TNF Family in Infectious Diseases and Interrelationship of the TNF Family and Pattern Recognition Receptor Signaling: Roles of the TNF Family in Infectious Diseases

    1. Front Matter

      Pages 169-169

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      Book Chapter

      Pages 171-175

      Workshop Summary: Functions of the TNF Family in Infectious Disease

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      Book Chapter

      Pages 177-186

      Role of 4-1BBL and TRAF1 in the CD8 T Cell Response to Influenza Virus and HIV

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      Book Chapter

      Pages 187-201

      Roles of Soluble and Membrane TNF and Related Ligands in Mycobacterial Infections: Effects of Selective and Non-selective TNF Inhibitors During Infection

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