Inflammation and Retinal Disease: Complement Biology and Pathology


ISBN: 978-1-4419-5634-7 (Print) 978-1-4419-5635-4 (Online)

Table of contents (11 chapters)

  1. Front Matter

    Pages i-xiii

  2. Chapter

    Pages 1-7

    The Case for Complement and Inflammation in AMD: Open Questions

  3. Chapter

    Pages 9-24

    The Role of Complement in AMD

  4. Chapter

    Pages 25-47

    Multiple Interactions of Complement Factor H with Its Ligands in Solution: A Progress Report

  5. Chapter

    Pages 49-62

    Genetic Control of Complement Activation in Humans and Age Related Macular Degeneration

  6. Chapter

    Pages 63-74

    Bisretinoids of RPE Lipofuscin: Trigger for Complement Activation in Age-Related Macular Degeneration

  7. Chapter

    Pages 75-93

    The Role of the Classical Complement Cascade in Synapse Loss During Development and Glaucoma

  8. Chapter

    Pages 95-104

    A Role for Complement in Glaucoma?

  9. Chapter

    Pages 105-125

    The ATP-Binding Cassette Transporter ABCA4: Structural and Functional Properties and Role in Retinal Disease

  10. Chapter

    Pages 127-135

    Suppression of Drusen Formation by Compstatin, a Peptide Inhibitor of Complement C3 activation, on Cynomolgus Monkey with Early-Onset Macular Degeneration

  11. Chapter

    Pages 137-149

    A Targeted Inhibitor of the Complement Alternative Pathway Reduces RPE Injury and Angiogenesis in Models of Age-Related Macular Degeneration

  12. Chapter

    Pages 151-162

    Complement Depletion with Humanized Cobra Venom Factor in a Mouse Model of Age-Related Macular Degeneration

  13. Back Matter

    Pages 163-167