Cancer Genome and Tumor Microenvironment

Editors:

ISBN: 978-1-4419-0710-3 (Print) 978-1-4419-0711-0 (Online)

Table of contents (20 chapters)

  1. Front Matter

    Pages i-xi

  2. Opening Remarks

    1. Front Matter

      Pages 1-1

    2. No Access

      Book Chapter

      Pages 3-8

      Hardwiring Tumor Progression

  3. Breaking Away: Epithelial-Mesenchymal Transition

    1. Front Matter

      Pages 9-9

    2. No Access

      Book Chapter

      Pages 11-32

      PI3K/AKT Pathway and the Epithelial-Mesenchymal Transition

    3. No Access

      Book Chapter

      Pages 33-66

      Loss of Cadherin-Catenin Adhesion System in Invasive Cancer Cells

    4. No Access

      Book Chapter

      Pages 67-91

      Rho GTPases in Regulation of Cancer Cell Motility, Invasion, and Microenvironment

    5. No Access

      Book Chapter

      Pages 93-115

      Merlin/NF2 Tumor Suppressor and Ezrin–Radixin–Moesin (ERM) Proteins in Cancer Development and Progression

  4. Coming up for Air: Hypoxia and Angiogenesis

    1. Front Matter

      Pages 117-117

    2. No Access

      Book Chapter

      Pages 119-132

      von Hippel-Lindau Tumor Suppressor, Hypoxia-Inducible Factor-1, and Tumor Vascularization

    3. No Access

      Book Chapter

      Pages 133-165

      RAS Oncogenes and Tumor-Vascular Interface

    4. No Access

      Book Chapter

      Pages 167-187

      Myc and Control of Tumor Neovascularization

    5. No Access

      Book Chapter

      Pages 189-216

      p53 and Angiogenesis

    6. No Access

      Book Chapter

      Pages 217-229

      Ink4a Locus: Beyond Cell Cycle

  5. Gaining New Ground: Metastasis and Stromal Cell Interactions

    1. Front Matter

      Pages 231-231

    2. No Access

      Book Chapter

      Pages 233-271

      Nm23 as a Metastasis Inhibitor

    3. No Access

      Book Chapter

      Pages 273-292

      HGF/c-MET Signaling in Advanced Cancers

    4. No Access

      Book Chapter

      Pages 293-314

      Contribution of ADAMs and ADAMTSs to Tumor Expansion and Metastasis

    5. No Access

      Book Chapter

      Pages 315-333

      Stromal Cells and Tumor Milieu: PDGF et al.

    6. No Access

      Book Chapter

      Pages 335-348

      TGF-β Signaling Alterations in Neoplastic and Stromal Cells

  6. Getting Attention: Immune Recognition and Inflammation

    1. Front Matter

      Pages 349-349

    2. No Access

      Book Chapter

      Pages 351-397

      Genetic Instability and Chronic Inflammation in Gastrointestinal Cancers

    3. No Access

      Book Chapter

      Pages 399-425

      Immunoglobulin Gene Rearrangements, Oncogenic Translocations, B-Cell Receptor Signaling, and B Lymphomagenesis

    4. No Access

      Book Chapter

      Pages 427-452

      Modulation of Philadelphia Chromosome-Positive Hematological Malignancies by the Bone Marrow Microenvironment

  7. Putting It All Together

    1. Front Matter

      Pages 453-453

    2. No Access

      Book Chapter

      Pages 455-469

      Melanoma: Mutations in Multiple Pathways at the Tumor-Stroma Interface

    3. No Access

      Book Chapter

      Pages 471-485

      Cooperation and Cancer

  8. Back Matter

    Pages 487-497