2009

Imaging in CNS Drug Discovery and Development

Implications for Disease & Therapy

ISBN: 978-1-4419-0133-0 (Print) 978-1-4419-0134-7 (Online)

Table of contents (23 chapters)

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  1. Front Matter

    Pages i-xviii

  2. Background

    1. Front Matter

      Pages 1-1

    2. No Access

      Book Chapter

      Pages 3-9

      The Challenges and Opportunities

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      Book Chapter

      Pages 11-28

      Imaging of CNS Systems: Importance for Drug Development

  3. Imaging Approaches

    1. Front Matter

      Pages 30-30

    2. No Access

      Book Chapter

      Pages 31-45

      Anatomical Imaging: Volumetric Analysis

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      Book Chapter

      Pages 47-65

      Diffusion Tensor Imaging and Drug Development

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      Book Chapter

      Pages 67-89

      Functional Magnetic Resonance Imaging in Drug Development

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      Book Chapter

      Pages 91-104

      Magnetic Resonance Imaging of Pharmacological Systems

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      Book Chapter

      Pages 105-119

      Molecular Imaging: Basic Approaches

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      Book Chapter

      Pages 121-133

      Chemical Imaging: Magnetic Resonance Spectroscopy: The Basics

  4. Imaging CNS Drug Action

    1. Front Matter

      Pages 136-136

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      Book Chapter

      Pages 137-151

      Animal Imaging

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      Book Chapter

      Pages 153-162

      Incorporating Functional MRI into Clinical Pharmacology Trials

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      Book Chapter

      Pages 163-176

      Imaging Placebo Responses in the Brain

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      Book Chapter

      Pages 177-190

      Structural Imaging of Drug Actions in Neurodegenerative Diseases

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      Book Chapter

      Pages 191-211

      Molecular Imaging of the CNS: Drug Actions

  5. Imaging CNS Disease States

    1. Front Matter

      Pages 214-214

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      Book Chapter

      Pages 215-228

      Translational MRI in CNS Drug Discovery

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      Book Chapter

      Pages 229-250

      In Vivo Mouse Imaging and Spectroscopy in Drug Discovery

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      Book Chapter

      Pages 251-261

      Neuroimaging in Understanding Chronic Pain Mechanisms and the Development of New Therapies

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      Book Chapter

      Pages 263-289

      Neuroimaging Human Drug Addiction

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      Book Chapter

      Pages 291-301

      Anxiety: Uncover Roles of Stress Related Genes by Imaging Genetics

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      Book Chapter

      Pages 303-318

      Imaging CNS Disease States: Alzheimer’s Disease

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      Book Chapter

      Pages 319-338

      Brain Development and CNS Plasticity

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