2009

Handbook on Immunosenescence

Basic Understanding and Clinical Applications

ISBN: 978-1-4020-9062-2 (Print) 978-1-4020-9063-9 (Online)

Table of contents (77 chapters)

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  1. Front Matter

    Pages i-xxxi

  2. Methods and Models for Studying Immunosenescence

    1. Front Matter

      Pages 2-2

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      Pages 3-28

      The Immune Risk Profile and Associated Parameters in Late Life: Lessons from the OCTO and NONA Longitudinal Studies

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      Pages 29-62

      Lymphocytes Sub-Types and Functions in Centenarians as Models for Successful Ageing

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      Pages 63-85

      Mouse Models and Genetics of Immunosenescence

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      Pages 87-105

      Insect Models of Immunosenescence

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      Pages 107-115

      Clonal Culture Models of T-cell Senescence

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      Pages 117-130

      Mouse Models of Influenza

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      Pages 131-144

      A Transgenic Dwarf Rat Strain as a Tool for the Study of Immunosenescence in Aging Rats and the Effect of Calorie Restriction

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      Book Chapter

      Pages 145-163

      Mathematical Modeling of Immunosenescence: Scenarios, Processes and Limitations

  3. Cellular Immunosenescene - T Cells

    1. Front Matter

      Pages 166-166

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      Pages 167-192

      Age, T-cell Homeostasis, and T-cell Diversity in Humans

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      Pages 193-202

      The Role of T-regulatory Cells in Immune Senescence

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      Pages 203-218

      Age-related Changes in Subpopulations of Peripheral Blood Lymphocytes in Healthy Japanese Population

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      Pages 219-233

      Age-associated T-cell Clonal Expansions (TCE) in vivo—Implications for Pathogen Resistance

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      Pages 235-255

      T-cell Cycle and Immunosenescence: Role of Aging in the T-cell Proliferative Behaviour and Status Quo Maintenance

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      Book Chapter

      Pages 257-276

      Mismatch Repair System and Aging: Microsatellite Instability in Peripheral Blood Cells of the Elderly and in the T-cell Clone Longitudinal Model

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      Book Chapter

      Pages 277-290

      Activation-Induced Cell Death of T-Cells in Elderly

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      Pages 291-325

      CD8 Clonal Expansions in Mice: An Age-associated Alteration of CD8 Memory T-cells

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      Book Chapter

      Pages 327-341

      Generation and Gene Expression of CD28-CD8 T-cells in Human

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      Book Chapter

      Pages 343-377

      Role of Regulatory Subsets During Aging

    12. Cellular Immunosenescence - B Cells

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        Book Chapter

        Pages 381-391

        Transcription Factors in Mature B-Cells During Aging

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        Book Chapter

        Pages 393-413

        B-Cell Repertoire Changes in Mouse Models of Aging

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