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The Paraoxonases: Their Role in Disease Development and Xenobiotic Metabolism

  • Book
  • © 2008

Overview

Editors:
  1. Bharti Mackness

    1. University of Manchester, U.K

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  2. Mike Mackness

    1. University of Manchester, U.K

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  3. Michael Aviram

    1. Technion Faculty of Medicine, Haifa, Israel

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  4. György Paragh

    1. University of Debrecen, Hungary

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  • Unique and novel enzyme whose physiological/ pathological function(s) just start to be revealed
  • Up to date information by invited speakers at September 2nd International Conference on Paraoxonases
  • Chapters by the leading international experts in their field
  • Covers the breadth of current research into the paraoxonases

Part of the book series: Proteins and Cell Regulation (PROR, volume 6)

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Table of contents (21 chapters)

  1. Front Matter

    Pages I-XV
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  2. The Bert La Du Memorial Lecture

    1. Front Matter

      Pages 1-1
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    2. Paraoxonases: An Historical Perspective

      • C.E. Furlong
      Pages 3-31

  3. PONs and Atherosclerosis

    1. Front Matter

      Pages 33-33
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    2. Glucose Inactivates Paraoxonase 1 (PON1) and Displaces it from High Density Lipoprotein (HDL) to a Free PON1 Form

      • Mira Rosenblat, Orly Sapir, Michael Aviram
      Pages 35-49

    3. Paraoxonase-1 and Cardiovascular Disease

      • B. Mackness, M.I. Mackness
      Pages 51-60

    4. Oxidative Stress & Antioxidants and PON1 in Health and Disease

      • Eser Yildirim Sozmen, Ferhan Girgin Sagin, Meral Kayikcioglu, Bulent Sozmen
      Pages 61-73

    5. D-4F Increases Paraoxonase 1 Activity in HDL

      • Greg Hough
      Pages 75-86

    6. Paraoxonase 1 (PON1), A Junction Between the Metabolisms of Homocysteine and Lipids

      • H. Jakubowski
      Pages 87-102

    7. The Role of PON2 and PON3 in Atherosclerosis and Related Traits

      • N. Bourquard, D.M. Shih, C.J. Ng, N. Villa-Garcia, K. Nakamura, D.A. Stoltz et al.
      Pages 103-128

    8. Paraoxonase 1 and Postprandial Lipemia

      • A. Alipour, B. Coll, A.P. Rietveld, J. Marsillach, J. Camps, J. Joven et al.
      Pages 129-138

    9. PON1 Genotypes and Coronary Heart Disease

      • M. Roest, H.A.M. Voorbij
      Pages 139-147

  4. PON1 Structure

    1. Front Matter

      Pages 149-149
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    2. Human Paraoxonase I: A Potential Bioscavenger of Organophosphorus Nerve Agents

      • David T. Yeung, David E. Lenz, Douglas M. Cerasoli
      Pages 151-170

    3. Stabilisation of Active Form of Natural Human PON1 Requires HPBP

      • D. Rochu, E. Chabriere, M. Elias, F. Renault, C. Clery-Barraud, P. Masson
      Pages 171-183

  5. PONs in Disease other than Atherosclerosis

    1. Front Matter

      Pages 185-185
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    2. Paraoxonase-1 in Chronic Liver Diseases, Neurological Diseases and HIV Infection

      • J. Marsillach, S. Parra, N. Ferré, B. Coll, C. Alonso-Villaverde, J. Joven et al.
      Pages 187-198

    3. Age-Related Alterations in PON1

      • I. Seres, T. Fulop, G. Paragh, A. Khalil
      Pages 199-206

  6. PON and Toxicology

    1. Front Matter

      Pages 207-207
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    2. Paraoxonase (PON1) and Organophosphate Toxicity

      • L.G. Costa, T.B. Cole, K.L. Jansen, C.E. Furlong
      Pages 209-220
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Keywords

About this book

Research into the paraoxonase (PON) multigene family has really only blossomed in the last 10 years. Before this time only PON1 was known and research was restricted to toxicologists investigating the metabolism of organophosphate insecticides and nerve gases and a few “mad” scientists searching for “natural” substrates.

Since this time two new members PON2 and PON3 have been discovered, all 3 PONs have been shown to act as antioxidants and the PON family has taken centre stage as major players in the development of a wide variety of diseases such as cardiovascular disease, diabetes mellitus, rheumatism, Alzheimer and many more while remaining important in determining organophosphate toxicity.

In September 2006 the 2nd International Conference on Paraoxonases took place in Hajdúszoboszló, Hungary, bringing together the world's foremost experts in the field. The current book is a distillation of the plenary lectures which took place at the meeting, resulting in a comprehensive up to date, state of the art review of current paraoxonase research.

Editors and Affiliations

  • University of Manchester, U.K

    Bharti Mackness, Mike Mackness

  • Technion Faculty of Medicine, Haifa, Israel

    Michael Aviram

  • University of Debrecen, Hungary

    György Paragh

Bibliographic Information

  • Book Title: The Paraoxonases: Their Role in Disease Development and Xenobiotic Metabolism

  • Editors: Bharti Mackness, Mike Mackness, Michael Aviram, György Paragh

  • Series Title: Proteins and Cell Regulation

  • DOI: https://doi.org/10.1007/978-1-4020-6561-3

  • Publisher: Springer Dordrecht

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media B.V. 2008

  • Hardcover ISBN: 978-1-4020-6560-6Published: 14 November 2007

  • Softcover ISBN: 978-90-481-7670-0Published: 25 November 2010

  • eBook ISBN: 978-1-4020-6561-3Published: 26 October 2007

  • Series ISSN: 1567-2530

  • Series E-ISSN: 2542-9973

  • Edition Number: 1

  • Number of Pages: XV, 325

  • Topics: Internal Medicine, Cardiology, Diabetes, Metabolic Diseases, Medical Biochemistry

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