The Paraoxonases: Their Role in Disease Development and Xenobiotic Metabolism

ISBN: 978-1-4020-6560-6 (Print) 978-1-4020-6561-3 (Online)

Table of contents (21 chapters)

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  1. Front Matter

    Pages I-XV

  2. The Bert La Du Memorial Lecture

    1. Front Matter

      Pages 1-1

    2. No Access

      Book Chapter

      Pages 3-31

      Paraoxonases: An Historical Perspective

  3. PONs and Atherosclerosis

    1. Front Matter

      Pages 33-33

    2. No Access

      Book Chapter

      Pages 35-49

      Glucose Inactivates Paraoxonase 1 (PON1) and Displaces it from High Density Lipoprotein (HDL) to a Free PON1 Form

    3. No Access

      Book Chapter

      Pages 51-60

      Paraoxonase-1 and Cardiovascular Disease

    4. No Access

      Book Chapter

      Pages 61-73

      Oxidative Stress & Antioxidants and PON1 in Health and Disease

    5. No Access

      Book Chapter

      Pages 75-86

      D-4F Increases Paraoxonase 1 Activity in HDL

    6. No Access

      Book Chapter

      Pages 87-102

      Paraoxonase 1 (PON1), A Junction Between the Metabolisms of Homocysteine and Lipids

    7. No Access

      Book Chapter

      Pages 103-128

      The Role of PON2 and PON3 in Atherosclerosis and Related Traits

    8. No Access

      Book Chapter

      Pages 129-138

      Paraoxonase 1 and Postprandial Lipemia

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      Book Chapter

      Pages 139-147

      PON1 Genotypes and Coronary Heart Disease

  4. PON1 Structure

    1. Front Matter

      Pages 149-149

    2. No Access

      Book Chapter

      Pages 151-170

      Human Paraoxonase I: A Potential Bioscavenger of Organophosphorus Nerve Agents

    3. No Access

      Book Chapter

      Pages 171-183

      Stabilisation of Active Form of Natural Human PON1 Requires HPBP

  5. PONs in Disease other than Atherosclerosis

    1. Front Matter

      Pages 185-185

    2. No Access

      Book Chapter

      Pages 187-198

      Paraoxonase-1 in Chronic Liver Diseases, Neurological Diseases and HIV Infection

    3. No Access

      Book Chapter

      Pages 199-206

      Age-Related Alterations in PON1

  6. PON and Toxicology

    1. Front Matter

      Pages 207-207

    2. No Access

      Book Chapter

      Pages 209-220

      Paraoxonase (PON1) and Organophosphate Toxicity

    3. No Access

      Book Chapter

      Pages 221-237

      Implications of Paraoxonase-1 (PON1) Activity and Polymorphisms on Biochemical and Clinical Outcomes in Workers Exposed to Pesticides

  7. PON-Genetics and Regulation

    1. Front Matter

      Pages 239-239

    2. No Access

      Book Chapter

      Pages 241-250

      Transcriptional Regulation of the Paraoxonase Genes

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      Book Chapter

      Pages 251-266

      Effect of Lipid Lowering Medications on PON1

    4. No Access

      Book Chapter

      Pages 267-281

      The Functional Consequences of Polymorphisms in the Human PON1 Gene

    5. No Access

      Book Chapter

      Pages 283-293

      Dietary Modulation of Paraoxonase-1 Activity and Concentration in Humans

  8. PONs Biochemistry

    1. Front Matter

      Pages 295-295

    2. No Access

      Book Chapter

      Pages 297-305

      PONs’ Natural Substrates – The Key for their Physiological Roles

  9. Back Matter

    Pages 321-325

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