Programmed Cell Death in Cancer Progression and Therapy

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ISBN: 978-1-4020-6553-8 (Print) 978-1-4020-6554-5 (Online)
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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xiv

  2. Book Chapter

    Pages 1-11

    Cell Death: History and Future

  3. Book Chapter

    Pages 13-23

    Caspase Mechanisms

  4. Book Chapter

    Pages 25-45

    The Mitochondrial Death Pathway

  5. Book Chapter

    Pages 47-79

    Apoptotic Pathways in Tumor Progression and Therapy

  6. Book Chapter

    Pages 81-104

    Therapeutic Targeting of Death Pathways in Cancer: Mechanisms for Activating Cell Death in Cancer Cells

  7. Book Chapter

    Pages 105-126

    Overcoming Resistance to Apoptosis in Cancer Therapy

  8. Book Chapter

    Pages 127-158

    Trail Receptors: Targets for Cancer Therapy

  9. Book Chapter

    Pages 159-175

    Rational Design of Therapeutics Targeting the BCL-2 Family: Are Some Cancer Cells Primed for Death but Waiting for a Final Push?

  10. Book Chapter

    Pages 177-200

    Autophagy and Tumor Suppression: Recent Advances in Understanding the Link between Autophagic Cell Death Pathways and Tumor Development

  11. Book Chapter

    Pages 201-221

    Regulation of Programmed Cell Death by the P53 Pathway

  12. Book Chapter

    Pages 223-250

    Regulation of Programmed Cell Death by NF-κB and its Role in Tumorigenesis and Therapy

  13. Book Chapter

    Pages 251-260

    Targeting Proteasomes as Therapy in Multiple Myeloma

  14. Book Chapter

    Pages 261-298

    Histone Deacetylase Inhibitors: Mechanisms and Clinical Significance in Cancer: HDAC Inhibitor-Induced Apoptosis

  15. Book Chapter

    Pages 299-329

    RNA Interference and Cancer: Endogenous Pathways and Therapeutic Approaches

  16. Book Chapter

    Pages 331-344

    Cancer Stem Cells and Impaired Apoptosis

  17. Back Matter

    Pages 345-356