2012

Mitochondrial Dysfunction in Neurodegenerative Disorders

ISBN: 978-0-85729-700-6 (Print) 978-0-85729-701-3 (Online)

Table of contents (13 chapters)

  1. Front Matter

    Pages i-xxi

  2. Mitochondrial Function and Genetics

    1. Front Matter

      Pages 1-1

    2. No Access

      Book Chapter

      Pages 3-18

      An Introduction to Mitochondria

  3. Mitochondrial Dysfunction: Causes and Effects?

    1. Front Matter

      Pages 19-19

    2. No Access

      Book Chapter

      Pages 21-41

      Neurodegeneration in Primary Mitochondrial Disorders

    3. No Access

      Book Chapter

      Pages 43-61

      Mutations in Nuclear Genes That Affect Mitochondrial Function in Parkinson’s Disease

    4. No Access

      Book Chapter

      Pages 63-78

      Common mtDNA Polymorphisms and Neurodegenerative Disorders

    5. No Access

      Book Chapter

      Pages 79-91

      mtDNA Mutations in Brain Aging and Neurodegeneration

  4. Functional Consequences of Mitochondrial Dysfunction

    1. Front Matter

      Pages 93-93

    2. No Access

      Book Chapter

      Pages 95-111

      Mitochondrial Dysfunction in Neurodegenerative Disease: Protein Aggregation, Autophagy, and Oxidative Stress

    3. No Access

      Book Chapter

      Pages 113-125

      Mitochondria, Sodium, and Calcium in Neuronal Dysfunction

    4. No Access

      Book Chapter

      Pages 127-139

      Mitochondrial Membrane Potential and Dynamics

    5. No Access

      Book Chapter

      Pages 141-155

      Dysfunction of the Ubiquitin/Proteasome System and Mitochondria in Neurodegenerative Disease

    6. No Access

      Book Chapter

      Pages 157-173

      Neuronal Mitochondrial Transport and Dysfunction

    7. No Access

      Book Chapter

      Pages 175-190

      Mitochondrial Changes Associated with Demyelination: Consequences for Axonal Integrity

  5. Modeling Mitochondrial Contribution to Neurodegenerative Disease

    1. Front Matter

      Pages 191-191

    2. No Access

      Book Chapter

      Pages 193-212

      Modeling Mitochondrial Dysfunction in Neurodegenerative Disease

  6. The Future

    1. Front Matter

      Pages 213-213

    2. No Access

      Book Chapter

      Pages 215-230

      Potential Therapies for Mitochondrial Dysfunction

  7. Back Matter

    Pages 231-242