Advances in Bioactivation Research

Editors:

ISBN: 978-0-387-77299-8 (Print) 978-0-387-77300-1 (Online)

Table of contents (19 chapters)

  1. Front Matter

    Pages 1-7

  2. General Concepts and Basic Mechanisms

    1. Front Matter

      Pages 1-1

    2. No Access

      Book Chapter

      Pages 1-24

      Metabolic Concerns in Drug Design

    3. No Access

      Book Chapter

      Pages 1-29

      Role of Bioactivation in Idiosyncratic Drug Toxicity: Structure–Toxicity Relationships

    4. No Access

      Book Chapter

      Pages 1-12

      Michael Addition–Elimination Reactions: Roles in Toxicity and Potential New Therapeutic Applications

    5. No Access

      Book Chapter

      Pages 1-34

      Induction of Drug-Metabolizing Enzymes: Contrasting Roles in Detoxification and Bioactivation of Drugs and Xenobiotics

    6. No Access

      Book Chapter

      Pages 1-29

      Mechanism-Based Inactivation of Cytochrome P450 2A and 2B Enzymes

    7. No Access

      Book Chapter

      Pages 1-36

      CYP2E1 – Biochemical and Toxicological Aspects and Role in Alcohol-Induced Liver Injury

    8. No Access

      Book Chapter

      Pages 1-29

      One- and Two-Electron-Mediated Reduction of Quinones: Enzymology and Toxicological Implications

    9. No Access

      Book Chapter

      Pages 1-34

      Lipoxidation-Derived Electrophiles as Biological Reactive Intermediates

    10. No Access

      Book Chapter

      Pages 1-21

      Bioactivation and Protein Modification Reactions of Unsaturated Aldehydes

  3. Tissue-Specific Features and Risk Assessment Applications

    1. Front Matter

      Pages 1-1

    2. No Access

      Book Chapter

      Pages 1-33

      Adaptive Responses and Signal Transduction Pathways in Chemically Induced Mitochondrial Dysfunction and Cell Death

    3. No Access

      Book Chapter

      Pages 1-33

      Hepatic Bioactivation and Drug-Induced Liver Injury

    4. No Access

      Book Chapter

      Pages 1-24

      Role of Cysteine S-Conjugate β-Lyases in the Bioactivation of Renal Toxicants

    5. No Access

      Book Chapter

      Pages 1-27

      Bioactivation of Xenobiotics in Lung: Role of CYPs and FMOs

    6. No Access

      Book Chapter

      Pages 1-34

      Generation of Reactive Metabolites and Associated DNA Adducts from Benzene, Butadiene, and PAH in Bone Marrow. Their Effects on Hematopoiesis and Impact on Human Health

    7. No Access

      Book Chapter

      Pages 1-31

      Butadiene-Mediated Mutagenesis and Carcinogenesis

    8. No Access

      Book Chapter

      Pages 1-20

      Pharmacogenetics of Drug Bioactivation Pathways

    9. No Access

      Book Chapter

      Pages 1-22

      Human Phenanthrene Metabolites as Probes for the Metabolic Activation and Detoxification of Carcinogenic Polycyclic Aromatic Hydrocarbons

  4. Back Matter

    Pages 1-19