ISBN: 978-0-387-76840-3 (Print) 978-0-387-76842-7 (Online)

Table of contents (15 chapters)

  1. Front Matter

    Pages i-xvii

  2. Chapter

    Pages 1-14

    Immune Risk Phenotypes and Associated Parameters in Very Old Humans: A Review of Findings in the Swedish NONA Immune Longitudinal Study

  3. Chapter

    Pages 15-23

    Scoring of Immunological Vigor: Trial Assessment of Immunological Status as a Whole for Elderly People and Cancer Patients

  4. Chapter

    Pages 24-33

    Remodelling of the CD8 T-Cell Compartment in the Elderly: Expression of NK Associated Receptors on T-Cells Is Associated with the Expansion of the Effector Memory Subset

  5. Chapter

    Pages 34-43

    Telomeres, Telomerase and CD28 in Human CD8 T-Cells: Effects on Immunity during Aging and HIV Infection

  6. Chapter

    Pages 44-56

    A Matter of Life and Death of T-Lymphocytes in Immunosenescence

  7. Chapter

    Pages 57-67

    T-Cell Signalling, a Complex Process for T-Cell Activation Compromised with Aging: When Membrane Rafts Can Simplify Everything

  8. Chapter

    Pages 68-79

    Immunosenescence, Thymic Involution and Autoimmunity

  9. Chapter

    Pages 80-91

    Autoimmune Diseases, Aging and the CD4+ Lymphocyte: Why Does Insulin-Dependent Diabetes Mellitus Start in Youth, but Rheumatoid Arthritis Mostly at Older Age?

  10. Chapter

    Pages 92-105

    Role of Chemokines and Chemokine Receptors in Diseases of Ageing

  11. Chapter

    Pages 106-120

    The Efficacy of Vaccines to Prevent Infectious Diseases in the Elderly

  12. Chapter

    Pages 121-128

    Zinc and the Altered Immune System in the Elderly

  13. Chapter

    Pages 129-136

    Zinc-Binding Proteins and Immunosenescence: Implications as Biological and Genetic Markers

  14. Chapter

    Pages 137-153

    Immunogenetics of Aging

  15. Chapter

    Pages 154-173

    The Genetics of Innate Immunity and Inflammation in Ageing, Age-Related Diseases and Longevity

  16. Chapter

    Pages 174-190

    SELDI Proteomics Approach to Identify Proteins Associated with T-Cell Clone Senescence

  17. Back Matter

    Pages 191-194