Oxidative Damage to Nucleic Acids

ISBN: 978-0-387-72973-2 (Print) 978-0-387-72974-9 (Online)

Table of contents (16 chapters)

  1. Front Matter

    Pages i-xvii

  2. Chapter

    Pages 1-13

    Oxidatively Generated Damage to Cellular DNA: Mechanistic Aspects

  3. Chapter

    Pages 14-39

    Chlorination and Nitration of DNA and Nucleic Acid Components

  4. Chapter

    Pages 40-53

    Prevention of the Mutagenicity and Cytotoxicity of Oxidized Purine Nucleotides

  5. Chapter

    Pages 54-66

    Nucleotide Incision Repair: An Alternative and Ubiquitous Pathway to Handle Oxidative DNA Damage

  6. Chapter

    Pages 67-80

    OGG1: From Structural Analysis to the Knockout Mouse

  7. Chapter

    Pages 81-90

    Processing of 3′-End Modified DNA Strand Breaks Induced by Oxidative Damage

  8. Chapter

    Pages 91-99

    Oxidative Damage and Promoter Function

  9. Chapter

    Pages 100-108

    Oxidative DNA Damage and Telomere Shortening

  10. Chapter

    Pages 109-122

    Oxidative Damage and Repair in the Mitochondrial Genome

  11. Chapter

    Pages 123-140

    The Role of Oxidative Damage to Nucleic Acids in the Pathogenesis of Neurological Disease

  12. Chapter

    Pages 141-152

    Nucleic Acid Oxidation and the Pathogenesis of Cardiovascular Diseases

  13. Chapter

    Pages 153-166

    Oxidative DNA Damage and Carcinogenesis

  14. Chapter

    Pages 167-177

    The Physiological and Pathological Roles of Oxidative Damage to DNA in Relation to Life Stage

  15. Chapter

    Pages 178-187

    Analysis of 8-Hydroxy-2′-Deoxyguanosine as a Marker of Oxidatively Damaged DNA in Relation to Carcinogenesis and Aging

  16. Chapter

    Pages 188-206

    Oxidatively Damaged DNA and Inflammation

  17. Chapter

    Pages 207-223

    The Role of Antioxidants in the Prevention of Oxidative Damage to Nucleic Acids

  18. Back Matter

    Pages 225-228