Book 2012

Genetically Engineered Mice for Cancer Research

design, analysis, pathways, validation and pre-clinical testing


ISBN: 978-0-387-69803-8 (Print) 978-0-387-69805-2 (Online)

Table of contents (28 chapters)

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  1. Front Matter

    Pages i-xx

  2. Chapter

    Pages 1-15

    Overview of Designing Genetically Engineered Mouse (GEM) Models

  3. Chapter

    Pages 17-36

    The Use of Cre–loxP Technology and Inducible Systems to Generate Mouse Models of Cancer

  4. Chapter

    Pages 37-56

    Using Recombineering Technology to Create Genetically Engineered Mouse Models

  5. Chapter

    Pages 57-82

    Insertional Mutagenesis for Generating Mouse Models of Cancer

  6. Chapter

    Pages 83-111

    The RCAS/TVA Somatic Gene Transfer Method in Modeling Human Cancer

  7. Chapter

    Pages 113-131

    Target-Selected ENU Mutagenesis to Develop Cancer Models in the Rat

  8. Chapter

    Pages 133-180

    The Tumor Pathology of Genetically Engineered Mice: Genomic Pathology

  9. Chapter

    Pages 181-191

    Genomic DNA Copy Number Alterations in Mouse Cancer Models and Human Cancer

  10. Chapter

    Pages 193-207

    Characterization of Chromosomal Translocations in Mouse Models of Hematological Malignancies Using Spectral Karyotyping, FISH, and Immunocytochemistry

  11. Chapter

    Pages 209-234

    Expression Profiling of Mouse Models of Human Cancer: Model Categorization and Guidance for Preclinical Testing

  12. Chapter

    Pages 235-260

    Imaging Mouse Models of Human Cancer

  13. Chapter

    Pages 261-279

    Identifying Mammary Epithelial Stem and Progenitor Cells

  14. Chapter

    Pages 281-292

    Differentiation Programs in Development and Cancer

  15. Chapter

    Pages 293-308

    Roles of p53 and pRB Tumor Suppressor Networks in Human Cancer: Insight from Studies in the Engineered Mouse

  16. Chapter

    Pages 309-329

    Mouse Models for Colorectal Cancer

  17. Chapter

    Pages 331-352

    Src Family Tyrosine Kinases: Implications for Mammary Tumor Progression

  18. Chapter

    Pages 353-373

    Maspin and Suppression of Tumor Metastasis

  19. Chapter

    Pages 375-396

    Epigenetic Mouse Models

  20. Chapter

    Pages 397-415

    Modeling Transforming Growth Factor-ß Signaling in Cancer

  21. Chapter

    Pages 417-442

    Modeling Stromal–Epithelial Interactions

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