2009

Androgen Action in Prostate Cancer

Editors:

ISBN: 978-0-387-69177-0 (Print) 978-0-387-69179-4 (Online)

Table of contents (33 chapters)

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  1. Front Matter

    Pages i-viii

  2. The Role of Androgens in Development of the Normal Prostate and Progression of Prostate Cancer

    1. Front Matter

      Pages 8-8

    2. No Access

      Book Chapter

      Pages 9-55

      Androgen Action and Modulation of Prostate and Prostate Cancer Growth: An Historical Perspective

    3. No Access

      Book Chapter

      Pages 57-72

      Clinical Progression to Castration-Recurrent Prostate Cancer

    4. No Access

      Book Chapter

      Pages 73-89

      Differential Roles of Androgen Receptor in Prostate Development and Cancer Progression

    5. No Access

      Book Chapter

      Pages 91-120

      Imaging Androgen Receptor Function In Vivo

  3. Androgen Metabolism

    1. Front Matter

      Pages 122-122

    2. No Access

      Book Chapter

      Pages 123-139

      Increased Expression of Genes Converting Adrenal Androgens to Testosterone in Castration-Recurrent Prostate Cancer

    3. No Access

      Book Chapter

      Pages 141-154

      Androgen-Metabolic Genes in Prostate Cancer Predisposition and Progression

    4. No Access

      Book Chapter

      Pages 155-173

      Effect of Steroid 5α-Reductase Inhibitors on Markers of Tumor Regression and Proliferation in Prostate Cancer

    5. No Access

      Book Chapter

      Pages 175-185

      5α-Reductase Isozymes in Castration-Recurrent Prostate Cancer

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      Book Chapter

      Pages 187-204

      Improving Intermittent Androgen-Deprivation Therapy: OFF Cycle and the Role of Steroid 5α-Reductase Inhibitors

  4. Androgen Receptor Structure/Function Relationships

    1. Front Matter

      Pages 206-206

    2. No Access

      Book Chapter

      Pages 207-240

      Insights from AR Gene Mutations

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      Book Chapter

      Pages 241-267

      Functional Motifs of the Androgen Receptor

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      Book Chapter

      Pages 269-295

      The Role of the Androgen Receptor Polyglutamine Tract in Prostate Cancer: In Mice and Men

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      Book Chapter

      Pages 297-311

      The Androgen Receptor Coactivator-Binding Interface

  5. Co-Regulators of the Androgen Receptor

    1. Front Matter

      Pages 314-314

    2. No Access

      Book Chapter

      Pages 315-340

      Coregulators and the Regulation of Androgen Receptor Action in Prostate Cancer

    3. No Access

      Book Chapter

      Pages 341-374

      Androgen Receptor Coregulators and Their Role in Prostate Cancer

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      Book Chapter

      Pages 375-384

      Interaction of the Androgen Receptor Ligand-Binding Domain with the N-Terminal Domain and with Coactivators

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      Book Chapter

      Pages 385-404

      Multitasking and Interplay Between the Androgen Receptor Domains

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      Book Chapter

      Pages 405-424

      Chromatin Remodeling and Androgen Receptor-Mediated Transcription

  6. Ligand-Independent Activation of the Androgen Receptor

    1. Front Matter

      Pages 426-426

    2. No Access

      Book Chapter

      Pages 427-449

      Ligand-Independent Androgen Receptor Activity

    3. No Access

      Book Chapter

      Pages 451-463

      Role of IL-6 in Regulating the Androgen Receptor

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