Book 2008

Tumor-Induced Immune Suppression

Mechanisms and Therapeutic Reversal


ISBN: 978-0-387-69117-6 (Print) 978-0-387-69118-3 (Online)

Table of contents (13 chapters)

  1. Front Matter

    Pages I-IX

  2. Chapter

    Pages 1-5

    Immune-Suppressive Mechanisms and Cancer: Understanding the Implications, Paradoxes, and Burning Questions

  3. Chapter

    Pages 7-27

    Mechanisms of Tumor-Associated T-Cell Tolerance

  4. Chapter

    Pages 29-40

    Contribution of B7-H1/PD-1 Co-inhibitory Pathway to T-Cell Dysfunction in Cancer

  5. Chapter

    Pages 41-67

    Regulatory T Cells in Cancer

  6. Chapter

    Pages 69-100

    Cancer-Induced Signaling Defects in Antitumor T Cells

  7. Chapter

    Pages 101-130

    Immunobiology of Dendritic Cells in Cancer

  8. Chapter

    Pages 131-155

    Macrophages and Tumor Development

  9. Chapter

    Pages 157-195

    Myeloid-Derived Suppressor Cells in Cancer

  10. Chapter

    Pages 197-218

    Signaling Pathways in Antigen-Presenting Cells Involved in the Induction of Antigen-Specific T-Cell Tolerance

  11. Chapter

    Pages 219-233

    Arginine Availability Regulates T-Cell Function in Cancer

  12. Chapter

    Pages 235-258

    Protein–Glycan Interactions in the Regulation of Immune Cell Function in Cancer: Lessons from the Study of Galectins-1 and -3

  13. Chapter

    Pages 259-280

    Role of Reactive Oxygen Species in T-Cell Defects in Cancer

  14. Chapter

    Pages 281-294

    Tumor Stroma and the Antitumor Immune Response

  15. Back Matter

    Pages 295-301