Hormonal Carcinogenesis V

ISBN: 978-0-387-69078-0 (Print) 978-0-387-69080-3 (Online)

Table of contents (65 chapters)

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  1. Front Matter

    Pages i-xlvi

  2. Symposium Address

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      Chapter

      Pages 3-13

      Relevance of the Concept of Oncogene Addiction to Hormonal Carcinogenesis and Molecular Targeting in Cancer Prevention and Therapy

  3. State of the Art Speakers

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      Chapter

      Pages 17-22

      What Can We Learn about Breast Cancer from Stem Cells?

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      Chapter

      Pages 23-40

      Ovarian Cancer: Linking Genomics to New Target Discovery and Molecular Markers — The Way Ahead

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      Chapter

      Pages 41-56

      Cdk1, Plks, Auroras, and Neks: The Mitotic Bodyguards

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      Chapter

      Pages 57-66

      Women’s Health Research: Perspectives from the National Institutes of Health

  4. Celluar Origins of Endocrine-related Cancers

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      Chapter

      Pages 69-78

      Stem Cells, Hormones, and Mammary Cancer

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      Chapter

      Pages 79-86

      The Origin of Estrogen Receptor α-Positive and α-Negative Breast Cancer

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      Chapter

      Pages 87-95

      Hormone Refractory Prostate Cancer: Lessons Learned from the PTEN Prostate Cancer Model

  5. Mitotic Kinases, Centrosome Amplification, and Genomic Instability

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      Chapter

      Pages 99-108

      Functional Significance of Aurora Kinase A in Centrosome Amplification and Genomic Instability

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      Chapter

      Pages 109-117

      Centrosome-Mediated Chromosomal Instability and Steroid Hormones as Co factors in Human Papillomavirus-Associated Cervical Carcinogenesis: Small Viruses Help to Answer Big Questions

  6. New Developments in Steroid Receptor Interactions

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      Chapter

      Pages 121-127

      Regulation of Hormone Signaling by Nuclear Receptor Interacting Proteins

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      Chapter

      Pages 129-138

      Dynamics of Estrogen Receptor-mediated Transcriptional Activation of Responsive Genes In Vivo: Apprehending Transcription in Four Dimensions

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      Chapter

      Pages 139-148

      Expression of Estrogen Receptors α and β in Early Steps of Human Breast Carcinogenesis

  7. Risk Assessment and Relevant Early Biomarkers

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      Chapter

      Pages 151-160

      Women’s Health Initiative Studies of Postmenopausal Breast Cancer

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      Chapter

      Pages 161-169

      Circulating Levels of Sex Steroids and Prolactin in Premenopausal Women and Risk of Breast Cancer

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      Chapter

      Pages 171-178

      Ovulation and Ovarian Cancer

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      Chapter

      Pages 179-190

      Prostate Cancer Susceptibility Loci: Finding the Genes

  8. Novel Strategies for Preventing and Treatment of Endocrine-related Cancers

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      Chapter

      Pages 193-199

      Strategy for the Application of Therapy in Prostate Cancer

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      Chapter

      Pages 201-211

      Response and Resistance to the Endocrine Prevention of Breast Cancer

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      Chapter

      Pages 213-220

      Estrogen-Induced Breast Oncogenesis: Modulation by an Aurora Kinase Inhibitor

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