2008

The Cancer Degradome

Proteases and Cancer Biology

ISBN: 978-0-387-69056-8 (Print) 978-0-387-69057-5 (Online)

Table of contents (41 chapters)

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  1. Front Matter

    Pages i-xxiii

  2. The Degradome and Its Analysis

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      Book Chapter

      Pages 3-15

      Protease Genomics and the Cancer Degradome

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      Book Chapter

      Pages 17-35

      The CLIP-CHIP™: A Focused Oligonucleotide Microarray Platform for Transcriptome Analysis of the Complete Human and Murine Cancer Degradomes

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      Book Chapter

      Pages 37-47

      The Hu/Mu ProtIn Chip: A Custom Dual-Species Oligonucleotide Microarray for Profiling Degradome Gene Expression in Tumors and Their Microenvironment

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      Book Chapter

      Pages 49-65

      Quantitative Real-Time PCR Analysis of Degradome Gene Expression

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      Book Chapter

      Pages 67-82

      Identification of Protease Substrates by Mass Spectrometry Approaches-1

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      Book Chapter

      Pages 83-100

      Identification of Protease Substrates by Mass Spectrometry Approaches-2

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      Book Chapter

      Pages 101-135

      Activity-Based Imaging and Biochemical Profiling Tools for Analysis of the Cancer Degradome

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      Book Chapter

      Pages 137-154

      Images of Cleavage: Tumor Proteases in Action

  3. Insights into Protease Function

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      Book Chapter

      Pages 157-182

      Proteolytic Pathways: Intersecting Cascades in Cancer Development

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      Book Chapter

      Pages 183-201

      Physiological Functions of Plasminogen Activation: Effects of Gene Deficiencies in Humans and Mice

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      Book Chapter

      Pages 203-221

      The Plasminogen Activation System in Tissue Remodeling and Cancer Invasion

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      Book Chapter

      Pages 223-243

      The Urokinase Plasminogen Activator Receptor as a Target for Cancer Therapy

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      Book Chapter

      Pages 245-258

      The Endocytic Collagen Receptor, uPARAP/Endo180, in Cancer Invasion and Tissue Remodeling

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      Book Chapter

      Pages 259-279

      Physiological and Pathological Functions of Type II Transmembrane Serine Proteases: Lessons from Transgenic Mouse Models and Human Disease-Associated Mutations

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      Book Chapter

      Pages 281-304

      Roles of Cysteine Proteases in Tumor Progression: Analysis of Cysteine Cathepsin Knockout Mice in Cancer Models

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      Book Chapter

      Pages 305-325

      In Vitro and In Vivo Models of Angiogenesis to Dissect MMP Functions

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      Book Chapter

      Pages 327-342

      The Surface Transplantation Model to Study the Tumor–Host Interface

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      Book Chapter

      Pages 343-360

      Unravelling the Roles of Proteinases in Cell Migration In Vitro and In Vivo

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      Book Chapter

      Pages 361-372

      New Insights into MMP function in Adipogenesis

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      Book Chapter

      Pages 373-400

      TIMPs: Extracellular Modifiers in Cancer Development

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