Prodrugs

Challenges and Rewards Part 1

ISBN: 978-0-387-49782-2 (Print) 978-0-387-49785-3 (Online)

Table of contents (57 chapters)

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  1. Front Matter

    Pages i-xvii

  2. A Case for Prodrugs

    1. Front Matter

      Pages 1-1

    2. No Access

      Book Chapter

      Pages 3-33

      A Case for Prodrugs

  3. Problems Addressable by Prodrugs

    1. Front Matter

      Pages 35-35

    2. Controlled Release

      1. No Access

        Book Chapter

        Pages 357-377

        Controlled Release — Small Molecules

      2. No Access

        Book Chapter

        Pages 379-416

        Controlled Release - Macromolecular Prodrugs

      3. No Access

        Book Chapter

        Pages 417-428

        Controlled Release - Proenzymes

      Targeting

      1. No Access

        Book Chapter

        Pages 429-445

        Targeting - Theoretical and Computational Models

      2. No Access

        Book Chapter

        Pages 447-506

        Targeting - Cancer — Small Molecules

      3. No Access

        Book Chapter

        Pages 507-524

        Monoclonal Antibody Drug Conjugates for Cancer Therapy

      4. No Access

        Book Chapter

        Pages 525-540

        Antibody-Directed Enzyme Prodrug Therapy

      5. No Access

        Book Chapter

        Pages 541-572

        Prodrugs for Liver-targeted Drug Delivery

      6. No Access

        Book Chapter

        Pages 573-651

        Prodrug Approaches for Drug Delivery to the Brain

      7. No Access

        Book Chapter

        Pages 653-682

        Lymphatic Absorption of Orally Administered Prodrugs

      8. No Access

        Book Chapter

        Pages 683-699

        Colonic Delivery

      Permeability

      1. No Access

        Book Chapter

        Pages 37-82

        Prodrug Approaches to Enhancing the Oral Delivery of Poorly Permeable Drugs

      2. No Access

        Book Chapter

        Pages 83-123

        Topical Delivery Using Prodrugs

      3. No Access

        Book Chapter

        Pages 125-155

        Prodrug approaches to ophthalmic drug delivery

      Solubility

      1. No Access

        Book Chapter

        Pages 157-215

        Overcoming Poor Aqueous Solubility of Drugs for Oral Delivery

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        Book Chapter

        Pages 217-281

        Prodrugs and Parenteral Drug Delivery

      Metabolism

      1. No Access

        Book Chapter

        Pages 283-338

        Poly (ethylene glycol) Prodrugs: Altered Pharmacokinetics and Pharmacodynamics

      2. No Access

        Book Chapter

        Pages 339-355

        Prodrugs to Reduce Presystemic Metabolism

  4. Functional Group Approach to Prodrugs

    1. Front Matter

      Pages 701-701

    2. No Access

      Book Chapter

      Pages 703-729

      Prodrugs of Carboxylic Acids

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