Optimizing the “Drug-Like” Properties of Leads in Drug Discovery

ISBN: 978-0-387-34056-2 (Print) 978-0-387-44961-6 (Online)

Table of contents (18 chapters)

  1. Front Matter

    Pages i-x

  2. No Access

    Book Chapter

    Pages 1-23

    Strategic Use of Preclinical Pharmacokinetic Studies and In Vitro Models in Optimizing ADME Properties of Lead Compounds

  3. No Access

    Book Chapter

    Pages 25-47

    Role of Mechanistic Transport Studies in Lead Optimization

  4. No Access

    Book Chapter

    Pages 49-80

    Metabolic Activation-Role in Toxicity and Idiosyncratic Reactions

  5. No Access

    Book Chapter

    Pages 81-97

    Case History — Use of ADME Studies for Optimization of Drug Candidates

  6. No Access

    Book Chapter

    Pages 99-130

    Solubility, Solubilization and Dissolution in Drug Delivery During Lead Optimization

  7. No Access

    Book Chapter

    Pages 131-150

    Lipid-based Systems, Drug Exposure and Lead Optimization

  8. No Access

    Book Chapter

    Pages 151-166

    Biopharmaceutics Modeling and the Role of Dose and Formulation on Oral Exposure

  9. No Access

    Book Chapter

    Pages 167-193

    Application of Physicochemical Data to Support Lead Optimization by Discovery Teams

  10. No Access

    Book Chapter

    Pages 195-219

    Computational Models Supporting Lead Optimization in Drug Discovery

  11. No Access

    Book Chapter

    Pages 221-242

    Prodrug Strategies for Improving Drug-Like Properties

  12. No Access

    Book Chapter

    Pages 243-254

    The Application of Multivariate Data Analysis to Compound Property Optimization

  13. No Access

    Book Chapter

    Pages 255-270

    Case History: Toxicology Biomarker Development Using Toxicogenomics

  14. No Access

    Book Chapter

    Pages 271-299

    Predicting Idiosyncratic Drug Reactions

  15. No Access

    Book Chapter

    Pages 301-322

    Elementary Predictive Toxicology for Advanced Applications

  16. No Access

    Book Chapter

    Pages 323-353

    The Application of PK/PD Modeling and Simulations During Lead Optimization

  17. No Access

    Book Chapter

    Pages 355-410

    Early Preclinical Evaluation of Brain Exposure in Support of Hit Identification and Lead Optimization

  18. No Access

    Book Chapter

    Pages 411-421

    Optimizing Biomarker Development for Clinical Studies at the Lead Optimization Stage of Drug Development

  19. No Access

    Book Chapter

    Pages 423-459

    The Relevance of Transporters in Determining Drug Disposition

  20. Back Matter

    Pages 461-511