Volume 6 2007

Protein Misfolding, Aggregation, and Conformational Diseases

Part B: Molecular Mechanisms of Conformational Diseases

Editors:

ISBN: 978-0-387-36529-9 (Print) 978-0-387-36534-3 (Online)

Table of contents (26 chapters)

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  1. Front Matter

    Pages i-xxv

  2. Altered Protein Structure and Enhanced Aggregation/Deposition

    1. Front Matter

      Pages 1-1

    2. A-Protein and Alzheimer’s Disease

      1. No Access

        Book Chapter

        Pages 3-29

        The Pathogenesis of Alzheimer’s Disease: General Overview

      2. No Access

        Book Chapter

        Pages 31-47

        Free Radicals, Metal Ions, and Aβ Aggregation and Neurotoxicity

      -Synuclein and Parkinson’s Disease

      1. No Access

        Book Chapter

        Pages 49-59

        Progress in Understanding the Mechanisms of Neuronal Dysfunction and Degeneration in Parkinson’s Disease

      2. No Access

        Book Chapter

        Pages 61-110

        α-Synuclein Aggregation and Parkinson’s Disease

      3. No Access

        Book Chapter

        Pages 111-124

        Cell Biology of α-Synuclein: Implications in Parkinson’s Disease and Other Lewy Body Diseases

      Prion Protein and Prion Diseases

      1. No Access

        Book Chapter

        Pages 125-146

        Pathogenesis of Prion Diseases

      2. No Access

        Book Chapter

        Pages 147-163

        Mammalian Prion Protein

      3. No Access

        Book Chapter

        Pages 165-182

        The Yeast Prion Proteins Sup35p and Ure2p

      4. No Access

        Book Chapter

        Pages 183-197

        Immunoglobulin Light Chain and Systemic Light-Chain Amyloidosis

      5. No Access

        Book Chapter

        Pages 199-216

        Pancreatic Islet Amyloid and Diabetes

      6. No Access

        Book Chapter

        Pages 217-239

        β2-Microglobulin and Dialysis-Related Amyloidosis

      7. No Access

        Book Chapter

        Pages 241-256

        Serum Amyloid A and AA Amyloidosis

  3. Point Mutations and Enhanced Protein Deposition

    1. Front Matter

      Pages 257-257

    2. No Access

      Book Chapter

      Pages 259-283

      Transthyretin and the Transthyretin Amyloidoses

    3. No Access

      Book Chapter

      Pages 285-308

      Human Lysozyme

    4. No Access

      Book Chapter

      Pages 309-323

      Serpins and the Diversity of Conformational Diseases

  4. Altered Protein Structure and Impaired Function

    1. Front Matter

      Pages 325-325

    2. No Access

      Book Chapter

      Pages 327-344

      Human Copper-Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis

    3. No Access

      Book Chapter

      Pages 345-361

      Understanding the Effects of Cancer-Associated Mutations in the Tumor Suppressor Protein p53: Structural Consequences of Mutations and Possible Ways of Rescuing Oncogenic Mutants

  5. Changes in Supramolecular Structure

    1. Front Matter

      Pages 363-363

    2. No Access

      Book Chapter

      Pages 365-389

      Protein Aggregation in Muscle Fibers and Respective Neuromuscular Disorders

    3. No Access

      Book Chapter

      Pages 391-407

      Muscular Dystrophies and Protein Mutations

    4. No Access

      Book Chapter

      Pages 409-433

      The Functional Consequences of Dystrophin Deficiency in Skeletal Muscles

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