2006

Misbehaving Proteins

Protein (Mis)Folding, Aggregation, and Stability

Authors:

ISBN: 978-0-387-30508-0 (Print) 978-0-387-36063-8 (Online)

Table of contents (15 chapters)

  1. Front Matter

    Pages I-VIII

  2. Introduction

    1. Front Matter

      Pages I-VIII

    2. No Access

      Book Chapter

      Pages 3-13

      Protein Folding, Misfolding, Stability, and Aggregation

  3. Mathematical Models and Computational Methods

    1. Front Matter

      Pages I-VIII

    2. No Access

      Book Chapter

      Pages 17-46

      Nonnative Protein Aggregation

    3. No Access

      Book Chapter

      Pages 47-77

      Simulations of Protein Aggregation

  4. Experimental Methods

    1. Front Matter

      Pages I-VIII

    2. No Access

      Book Chapter

      Pages 81-98

      Elucidating Structure, Stability, and Conformational Distributions during Protein Aggregation with Hydrogen Exchange and Mass Spectrometry

    3. No Access

      Book Chapter

      Pages 99-123

      Application of Spectroscopic and Calorimetric Techniques in Protein Formulation Development

    4. No Access

      Book Chapter

      Pages 125-146

      Small-Angle Neutron Scattering as a Probe for Protein Aggregation at Many Length Scales

    5. No Access

      Book Chapter

      Pages 147-165

      Laser Light Scattering as an Indispensable Tool for Probing Protein Aggregation

    6. No Access

      Book Chapter

      Pages 167-191

      X-ray Diffraction for Characterizing Structure in Protein Aggregates

    7. No Access

      Book Chapter

      Pages 193-214

      Glass Dynamics and the Preservation of Proteins

  5. Fundamental Studies in Model Systems

    1. Front Matter

      Pages I-VIII

    2. No Access

      Book Chapter

      Pages 217-245

      Folding and Misfolding as a Function of Polypeptide Chain Elongation

    3. No Access

      Book Chapter

      Pages 247-264

      Determinants of Protein Folding and Aggregation in P22 Tailspike Protein

    4. No Access

      Book Chapter

      Pages 265-285

      Factors Affecting the Fibrillation of α-Synuclein, a Natively Unfolded Protein

    5. No Access

      Book Chapter

      Pages 287-309

      Molten Globule-Lipid Bilayer Interactions and Their Implications for Protein Transport and Aggregation

  6. Protein Product Development

    1. Front Matter

      Pages I-VIII

    2. No Access

      Book Chapter

      Pages 313-330

      Self-Association of Therapeutic Proteins

    3. No Access

      Book Chapter

      Pages 331-350

      Mutational Approach to Improve Physical Stability of Protein Therapeutics Susceptible to Aggregation

  7. Back Matter

    Pages 351-353