Complex Systems Science in Biomedicine

ISBN: 978-0-387-30241-6 (Print) 978-0-387-33532-2 (Online)

Table of contents (36 chapters)

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  1. Front Matter

    Pages i-xix

  2. Introduction

    1. Front Matter

      Pages 1-1

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      Book Chapter

      Pages 3-29

      Integrative Systems View of Life: Perspectives from General Systems Thinking

  3. Complex Systems Science: The Basics

    1. Front Matter

      Pages 31-31

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      Book Chapter

      Pages 33-114

      Methods and Techniques of Complex Systems Science: An Overview

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      Book Chapter

      Pages 115-140

      Nonlinear Dynamical Systems

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      Pages 141-163

      Biological Scaling and Physiological Time: Biomedical Applications

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      Pages 165-181

      The Architecture of Biological Networks

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      Pages 183-205

      Robustness in Biological Systems: A Provisional Taxonomy

  4. Complex Adaptive Biosystems: A Multi-Scaled Approach

    1. Front Matter

      Pages 207-207

    2. Complexity in Molecular Networks

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        Book Chapter

        Pages 211-226

        Noise in Gene Regulatory Networks

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        Pages 227-245

        Modeling RNA Folding

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        Book Chapter

        Pages 247-263

        Protein Networks

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        Pages 265-280

        Electronic Cell Environments: Combining Gene, Protein, and Metabolic Networks

      The Cell as a Complex System

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        Pages 283-310

        Tensegrity, Dynamic Networks, and Complex Systems Biology: Emergence in Structural and Information Networks Within Living Cells

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        Book Chapter

        Pages 311-332

        Spatiotemporal Dynamics of Eukaryotic Gradient Sensing

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        Book Chapter

        Pages 333-353

        Patterning by EGF Receptor: Models from Drosophila Development

      Developmental Biology and The Cardiac System

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        Pages 357-374

        Developmental Biology: Branching Morphogenesis

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        Pages 375-407

        Modeling Cardiac Function

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        Pages 409-422

        Cardiac Oscillations and Arrhythmia Analysis

      The Immune System

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        Pages 425-436

        How Distributed Feedbacks from Multiple Sensors Can Improve System Performance: Immunology and Multiple-Organ Regulation

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        Book Chapter

        Pages 437-450

        Microsimulation of Inducible Reorganization in Immunity

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        Book Chapter

        Pages 451-459

        The Complexity of the Immune System: Scaling Laws

      The Nervous System

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        Book Chapter

        Pages 463-482

        Neurobiology and Complex Biosystem Modeling

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