The Nidoviruses

1. Viral RNA Synthesis

   1. Transcriptional Regulation of RNA3 of Infectious Bronchitis Virus

      • Soonjeon Youn, Ellen W. Collisson, Carolyn E. Machamer

      Pages 109-112

2. Protein Synthesis, Structure, and Processing

   1. Front Matter

      Pages 114-114

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   2. Structure, Expression, and Intracellular Localization of the SARS-CoV Accessory Proteins 7a and 7b

      • Andrew Pekosz, Scott R. Schaecher, Michael S. Diamond, Daved H. Fremont, Amy C. Sims, Ralph S. Baric

      Pages 115-120

   3. Sumoylation of the Nucleocapsid Protein of Severe Acute Respiratory Syndrome Coronavirus by Interaction with UBC9

      • Qisheng Li, Han Xiao, James P. Tam, Ding X. Liu

      Pages 121-126

   4. Importance of MHV-CoV A59 Nucleocapsid Protein Cooh-Terminal Negative Charges

      • Valerie Bednar, Sandhya Verma, Andrew Blount, Brenda G. Hogue

      Pages 127-132

   5. Expression and Structural Analysis of Infectious Bronchitis Virus Nucleoprotein

      • Kelly-Anne Spencer, Julian A. Hiscox

      Pages 133-138

   6. Mouse Hepatitis Virus Infection Activates the IRE1/XBP1 Pathway of the Unfolded Protein Response

      • John Bechill, Zhongbin Chen, Joseph W. Brewer, Susan C. Baker

      Pages 139-144

   7. The Nuclear Localization Signal of the Prrs Virus Nucleocapsid Protein Modulates Viral Replication in vitro and Antibody Response in vivo

      • Changhee Lee, Douglas C. Hodgins, Jay G. Calvert, Siao-Kun Wan Welch, Rika Jolie, Dongwan Yoo

      Pages 145-148

   8. Sars Coronavirus Accessory ORFs Encode Luxury Functions

      • Matthew B. Frieman, Boyd Yount, Amy C. Sims, Damon J. Deming, Thomas E. Morrison, Jennifer Sparks et al.

      Pages 149-152

   9. Production and Characterization of Monoclonal Antibodies Against the Nucleocapsid Protein of SARS-COV

      • Ying Fang, Andrew Pekosz, Lia Haynes, Eric A. Nelson, Raymond R. R. Rowland

      Pages 153-156

   10. Mouse Hepatitis Coronavirus Nucleocapsid Phosphorylation

       • Tiana C. White, Brenda G. Hogue

       Pages 157-160

3. Viral Assembly and Release

   1. Front Matter

      Pages 162-162

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   2. Genetic and Molecular Biological Analysis of Protein-Protein Interactions in Coronavirus Assembly

      • Paul S. Masters, Lili Kuo, Rong Ye, Kelley R. Hurst, Cheri A. Koetzner, Bilan Hsue

      Pages 163-173

   3. New Insights on the Structure and Morphogenesis of Berne Virus

      • Ana Garzón, Ana M. Maestre, Jaime Pignatelli, M. Teresa Rejas, Dolores Rodríguez

      Pages 175-180

   4. Ultrastructure of SARS-CoV, FIPV, and MHV Revealed by Electron Cryomicroscopy

      • Benjamin W. Neuman, Brian D. Adair, Craig Yoshioka, Joel D. Quispe, Ronald A. Milligan, Mark Yeager et al.

      Pages 181-185

   5. Role of Mouse Hepatitis Coronavirus Envelope Protein Transmembrane Domain

      • Ye Ye, Brenda G. Hogue

      Pages 187-191

   6. The Transmembrane Domain of the Infectious Bronchitis Virus E Protein is Required for Efficient Virus Release

      • Carolyn E. Machamer, Soonjeon Youn

      Pages 193-198

   7. Viroporin Activity of SARS-CoV E Protein

      • Ying Liao, James P. Tam, Ding X. Liu

      Pages 199-202

   8. Efficient Transduction of Dendritic Cells Using Coronavirus-Based Vectors

      • Klara K. Eriksson, Divine Makia, Reinhard Maier, Luisa Cervantes, Burkhard Ludewig, Volker Thiel

      Pages 203-206

4. Viral Entry

   1. Front Matter

      Pages 208-208

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This book summarizes the keynote and plenary speeches and posters of the Xth International Nidovirus Symposium: Toward Control of SARS and Other Nidovirus Diseases” that was held in Colorado Springs, Colorado, June 25–30, 2005. The nine previous meetings of scientists investigating the molecular biology and pathogenesis of coronaviruses, toroviruses, arteriviruses, and okaviruses were generally held every 3 years since the first meeting was convened in Wurzburg, Germany, in October, 1980. The Xth International Symposium was held just 2 years after the IXth International Symposium (Nido2003) in The Netherlands, because of the tremendously increased research on nidoviruses that resulted from the discovery that the global epidemic of severe acute res- ratory syndrome (SARS) in 2002–2003 was caused by a newly discovered coronavirus called SARS-CoV. A record 225 scientists from 14 countries attended the Xth International Nidovirus Symposium, and important advances in every aspect of nidovirus molecular biology and pathogenesis were reported and discussed. The meeting was divided into 12 sessions, with keynote speakers providing a general review of research pertinent to each one. This volume is a collection of scientific papers presented at the symposium. Once a coronavirus was recognized as the etiological agent of SARS, intensive work by many investigators resulted in determination of the sequence of the virus, engineering of reverse genetics systems, and identification of the host cell receptor used by the virus. With the increased interest in coronaviruses, new members of the family associated with human disease were identified.

• RNA
• antiviral drug
• diagnostics
• diseases
• pathogenesis
• protein
• vaccine
• virus
• infectious diseases

• Department of Pediatrics, University of Iowa, Iowa City, USA

  Stanley Perlman

• Department of Microbiology, University of Colorado Health Sciences Center at Fitzsimons, Aurora, USA

  Kathryn V. Holmes

Policies and ethics