Book 2009


Physiology and Disease


ISBN: 978-0-387-09636-0 (Print) 978-0-387-09637-7 (Online)

Table of contents (13 chapters)

  1. Front Matter

    Pages i-xii

  2. Chapter

    Pages 1-18

    Thrombin: Structure, Functions, and Regulation

  3. Chapter

    Pages 19-46

    Thrombin: To PAR or Not to PAR, and the Regulation of Inflammation

  4. Chapter

    Pages 47-61

    Regulation of Thrombin Receptor Signaling

  5. Chapter

    Pages 63-80

    Thrombin-Activated Protein C: Integrated to Regulate Vascular Physiology

  6. Chapter

    Pages 81-92

    The Role of Thrombin in Vascular Development

  7. Chapter

    Pages 93-113

    The Role of Thrombin in Angiogenesis

  8. Chapter

    Pages 115-132

    Thrombin and Thrombin Peptides in Wound Healing and Tissue Repair

  9. Chapter

    Pages 133-159

    The Role of Thrombin and Thrombin Receptors in the Brain

  10. Chapter

    Pages 161-172

    The Role of Thrombin in Tumor Biology

  11. Chapter

    Pages 173-188

    The Role of Thrombin and its Receptors in Epithelial Malignancies: Lessons from a Transgenic Mouse Model and Transcriptional Regulation

  12. Chapter

    Pages 189-203

    Anti-thrombotic Therapy in Cancer Patients

  13. Chapter

    Pages 205-236

    Thrombin Receptor Modulators: Medicinal Chemistry, Biological Evaluation, and Clinical Application

  14. Chapter

    Pages 237-257

    Novel Anticoagulant Therapy: Principle and Practice

  15. Back Matter

    Pages 259-266