Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery

Editors:

ISBN: 978-3-540-30157-8 (Print) 978-3-540-30328-2 (Online)

Table of contents (31 chapters)

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  1. Setting the Scene

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      Pages 1-14

      Setting the Scene

  2. The Inflammatory Response

    1. Front Matter

      Pages 15-15

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      Pages 17-33

      Genetics and Severe Sepsis

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      Pages 35-53

      Cell Signaling Pathways of the Innate Immune System During Acute Inflammation

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      Pages 55-66

      Early-Onset Pro-inflammatory Cytokines

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      Pages 67-75

      The Significance of HMGB1, a Late-Acting Pro-inflammatory Cytokine

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      Pages 77-95

      Nitric Oxide

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      Pages 97-111

      Involvement of Reactive Oxygen and Nitrogen Species in the Pathogenesis of Acute Lung Injury

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      Pages 113-121

      Heat Shock Proteins in Inflammation

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      Pages 123-135

      Fibrosis in the Acute Respiratory Distress Syndrome

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      Pages 137-157

      Resolution of Inflammation

  3. The Cellular Immune Respone

    1. Front Matter

      Pages 159-159

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      Pages 161-182

      Compartmentalized Activation of Immune Cells During Sepsis and Organ Dysfunction

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      Pages 183-201

      The Neutrophil in the Pathogenesis of Multiple Organ Dysfunction Syndrome

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      Pages 203-210

      The Role of the Macrophage

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      Pages 211-227

      The Role of the Endothelium

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      Pages 229-235

      Differential Effects of Pro-Inflammatory Mediators on Alveolar Epithelial Barrier Function

  4. Mechanisms and Pathways of Dysfunction

    1. Front Matter

      Pages 237-237

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      Pages 239-247

      Macrocirculatory Disturbances

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      Pages 249-262

      The Microcirculation Is a Vulnerable Organ in Sepsis

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      Pages 263-272

      The Cholinergic Anti-inflammatory Pathway: Connecting the Mind and Body

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      Pages 273-285

      Coagulation in Sepsis

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      Pages 287-297

      The Role of Insulin and Blood Glucose Control

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