Molecular Chaperones in Health and Disease


ISBN: 978-3-540-25875-9 (Print) 978-3-540-29717-8 (Online)

Table of contents (17 chapters)

  1. Front Matter

    Pages I-IX

  2. Chapter

    Pages 1-42

    Chaperones in Preventing Protein Denaturation in Living Cells and Protecting Against Cellular Stress

  3. Chapter

    Pages 43-68

    Feedback Regulation of the Heat Shock Response

  4. Chapter

    Pages 69-91

    Protein Folding in the Endoplasmic Reticulum and the Unfolded Protein Response

  5. Chapter

    Pages 93-109

    Molecular Chaperones in Signal Transduction

  6. Chapter

    Pages 111-138

    Chaperoning of Glucocorticoid Receptors

  7. Chapter

    Pages 139-152

    Heat Shock Response: Lessons from Mouse Knockouts

  8. Chapter

    Pages 153-169

    HSFs in Development

  9. Chapter

    Pages 171-198

    Heat Shock Proteins: Endogenous Modulators of Apoptotic Cell Death

  10. Chapter

    Pages 199-219

    Protein Aggregation as a Cause for Disease

  11. Chapter

    Pages 221-258

    The Role of Chaperones in Parkinson’s Disease and Prion Diseases

  12. Chapter

    Pages 259-277

    Chaperoning Oncogenes: Hsp90 as a Target of Geldanamycin

  13. Chapter

    Pages 279-304

    Heat Shock Proteins in Immunity

  14. Chapter

    Pages 305-329

    Molecular Chaperones and Cancer Immunotherapy

  15. Chapter

    Pages 331-358

    Hsp90 Inhibitors in the Clinic

  16. Chapter

    Pages 359-404

    Pharmacological Targeting of Catalyzed Protein Folding: The Example of Peptide Bond cis/trans Isomerases

  17. Chapter

    Pages 405-416

    Chemical Chaperones: Mechanisms of Action and Potential Use

  18. Chapter

    Pages 417-436

    Pharmacological Modulation of the Heat Shock Response

  19. Back Matter

    Pages 437-442