CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential

ISBN: 978-3-540-24444-8 (Print) 978-3-540-27702-6 (Online)

Table of contents (14 chapters)

  1. Front Matter

    Pages I-XI

  2. Origin and Generation

    1. Chapter

      Pages 1-23

      Selection of CD4+CD25+ Regulatory T Cells by Self-Peptides

    2. Chapter

      Pages 25-42

      The Role of TCR Specificity in Naturally Arising CD25+ CD4+ Regulatory T Cell Biology

    3. Chapter

      Pages 43-71

      Thymic Commitment of Regulatory T Cells Is a Pathway of TCR-Dependent Selection That Isolates Repertoires Undergoing Positive or Negative Selection

    4. Chapter

      Pages 73-87

      Selection and Behavior of CD4+ CD25+ T Cells In Vivo: Lessons from T Cell Receptor Transgenic Models

    5. Chapter

      Pages 89-114

      Migration Rules: Functional Properties of Naive and Effector/Memory-Like Regulatory T Cell Subsets

    6. Chapter

      Pages 115-131

      Peripheral Generation and Function of CD4+CD25+ Regulatory T Cells

    7. Chapter

      Pages 133-150

      Dendritic Cells: Key Cells for the Induction of Regulatory T Cells?

  3. Involvement of Disease Models

    1. Chapter

      Pages 153-177

      Autoimmune Gastritis Is a Well-Defined Autoimmune Disease Model for the Study of CD4+CD25+ T Cell-Mediated Suppression

    2. Chapter

      Pages 179-208

      Regulatory T Cells in Experimental Colitis

    3. Chapter

      Pages 209-247

      Autoimmune Ovarian Disease in Day 3-Thymectomized Mice: The Neonatal Time Window, Antigen Specificity of Disease Suppression, and Genetic Control

    4. Chapter

      Pages 249-264

      Regulatory T Cells in Transplantation Tolerance

    5. Chapter

      Pages 265-285

      CD4+CD25+ Regulatory T Cells in Hematopoietic Stem Cell Transplantation

    6. Chapter

      Pages 287-302

      Naturally Arising CD25+CD4+ Regulatory T Cells in Tumor Immunity

    7. Chapter

      Pages 303-326

      Phenotypic and Functional Differences Between Human CD4+CD25+ and Type 1 Regulatory T Cells

  4. Back Matter

    Pages 327-330