Book Volume 42 2007

Inflammation in the Pathogenesis of Chronic Diseases

The COX-2 Controversy

ISBN: 978-1-4020-5687-1 (Print) 978-1-4020-5688-8 (Online)

Table of contents (14 chapters)

  1. Front Matter

    Pages I-XIII

  2. Historical Perspectives

    1. Front Matter

      Pages 1-1

    2. Chapter

      Pages 3-27

      Anti-Inflammatory Drugs in the 21st Century

  3. Inflammatory Mechanisms of Pathogenesis

    1. Front Matter

      Pages 29-29

    2. Chapter

      Pages 31-62

      Nitric Oxide Synthase and Cyclooxygenase Interactions in Cartilage and Meniscus

    3. Chapter

      Pages 63-91

      Obesity, Inflammation, and Vascular Disease

    4. Chapter

      Pages 93-126

      Cyclooxygenase-2 (COX-2) and the Inflammogenesis of Cancer

    5. Chapter

      Pages 127-141

      Role of COX-2 in Inflammatory and Degenerative Brain Diseases

  4. Inflammation and Cardiovascular Disease: The Coxib Controversy

    1. Front Matter

      Pages 143-143

    2. Chapter

      Pages 145-158

      Cardiovascular Effects of the Selective Cyclooxygenase-2 Inhibitors

    3. Chapter

      Pages 159-174

      COX-2 Inhibitors And Cardiovascular Risk

    4. Chapter

      Pages 175-190

      A Biological Rationale for the Cardiotoxic Effects of Rofecoxib

  5. Cox-2 Blockade in Cancer Prevention and Therapy

    1. Front Matter

      Pages 191-191

    2. Chapter

      Pages 193-212

      Cancer Chemoprevention by Cyclooxygenase 2 (COX-2) Blockade

    3. Chapter

      Pages 213-225

      Strategies for Colon Cancer Prevention

  6. Inflammation and Neurodegenerative Disease

    1. Front Matter

      Pages 227-227

    2. Chapter

      Pages 229-248

      NSAIDs for the Chemoprevention of Alzheimer’s Disease

    3. Chapter

      Pages 249-279

      Inflammation in parkinson’s disease

  7. Nutrition, Inflammation and Chronic Disease

    1. Front Matter

      Pages 281-281

    2. Chapter

      Pages 283-297

      Essential Polyunsaturated Fatty Acids, Inflammation, Atherosclerosis and Cardiovascular Diseases

    3. Chapter

      Pages 299-318

      Nutritional Intervention in Brain Aging

  8. Back Matter

    Pages 319-323