Genome Instability in Cancer Development

ISBN: 978-1-4020-3763-4 (Print) 978-1-4020-3764-1 (Online)

Table of contents (17 chapters)

  1. The Problem of Genome Instability

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      Book Chapter

      Pages 3-17

      The Multiplicity of Mutations in Human Cancers

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      Book Chapter

      Pages 19-41

      Monitoring Chromosome Rearrangements

  2. DNA Repair and Mutagenesis

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      Book Chapter

      Pages 45-83

      Nucleotide Excision Repair and its Connection with Cancer and Ageing

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      Book Chapter

      Pages 85-123

      DNA Mismatch Repair and Colon Cancer

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      Book Chapter

      Pages 125-173

      Base Excision Repair

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      Book Chapter

      Pages 175-197

      Genomic Instability in Cancer Development

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      Book Chapter

      Pages 199-223

      Translesion Synthesis And Errorprone Polymerases

  3. Cell Cycle Progression and Chromosome Aberration

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      Book Chapter

      Pages 227-247

      The INK4A/Arf Network — Cell Cycle Checkpoint or Emergency Brake?

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      Book Chapter

      Pages 249-279

      DNA Replication and Genomic Instability

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      Book Chapter

      Pages 281-310

      The Dream of Every Chromosome: Equal Segregation for a Healthy Life of the Host

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      Book Chapter

      Pages 311-341

      Telomere Structural Dynamics in Genome Integrity Control and Carcinogenesis

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      Book Chapter

      Pages 343-361

      Gene Amplification Mechanisms

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      Book Chapter

      Pages 363-392

      DNA Methylation and Cancer-associated Genetic Instability

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      Book Chapter

      Pages 393-421

      Deregulation of the Centrosome Cycle and the Origin of Chromosomal Instability in Cancer

  4. Genome Integrity Checkpoints

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      Book Chapter

      Pages 425-455

      Mammalian DNA Damage Response Pathway

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      Book Chapter

      Pages 457-476

      ATM and Cellular Response to DNA Damage

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      Book Chapter

      Pages 477-499

      Mitotic Checkpoint, Aneuploidy and Cancer