2006

Statistics Applied to Clinical Trials

Authors:

ISBN: 978-1-4020-4229-4 (Print) 978-1-4020-0570-1 (Online)

Table of contents (31 chapters)

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  1. Front Matter

    Pages i-xii

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    Book Chapter

    Pages 1-16

    Hypotheses, Data, Stratification

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    Book Chapter

    Pages 17-39

    The Analysis of Efficacy Data of Drug Trials

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    Pages 41-58

    The Analysis of Safety Data of Drug Trials

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    Pages 59-65

    Equivalence Testing

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    Pages 67-78

    Statiscal Power and Sample Size

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    Pages 79-85

    Interim Analyses

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    Pages 87-96

    Multiple Statistical Inferences

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    Pages 97-101

    Controlling the Risk of False Positive Clinical Trials

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    Pages 103-115

    The Interpretation of the P-Values

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    Pages 117-123

    Research Data Closer to Expectation than Compatible with Random Sampling

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    Pages 125-140

    Principles of Linear Regression

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    Pages 141-150

    Subgroup Analysis Using Multiple Linear Regression: Confounding, Interaction, Synergism

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    Pages 151-163

    Curvilinear Regression

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    Pages 165-178

    Logistic and Cox Regression, Problems with Regression Modeling, Markow Models

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    Pages 179-185

    Regression Modeling for Improved Precision

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    Pages 187-191

    Post-Hoc Analyses in Clinical Trials, A Case for Logistic Regression Analysis

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    Pages 193-204

    Interaction Effects in Clinical Trials

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    Pages 205-218

    Meta-Analysis

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    Pages 219-228

    Crossover Studies with Continous Variables: Power Analysis

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    Book Chapter

    Pages 229-237

    Crossover Studies with Binary Responses

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