Mechanisms of Lymphocyte Activation and Immune Regulation XI

B Cell Biology

  • Sudhir Gupta
  • Frederick Alt
  • Max Cooper
  • Fritz Melchers
  • Klaus Rajewsky
Conference proceedings

DOI: 10.1007/0-387-46530-8

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 596)

Table of contents

  1. Front Matter
    Pages I-IX
  2. David Savitsky, Luisa Cimmino, Tracy Kuo, Gislâine A. Martins, Kathryn Calame
    Pages 9-30
  3. Louise J. McHeyzer-Williams, Michael G. McHeyzer-Williams
    Pages 31-45
  4. Randall J. Brezski, John G. Monroe
    Pages 47-55
  5. Harinder Singh, Jagan M. R. Pongubala, Kay L. Medina
    Pages 57-62
  6. Fritz Melchers, Tamotsu Yamagami, Antonius Rolink, Jan Andersson
    Pages 63-70
  7. Reiko Shinkura, Il-mi Okazaki, Taro Muto, Nasim A. Begum, Tasuku Honjo
    Pages 71-81
  8. Ursula Storb, Hong Ming Shen, Simonne Longerich, Sarayu Ratnam, Atsushi Tanaka, Grazyna Bozek et al.
    Pages 83-91
  9. Ziqiang Li, Zhonghui Luo, Diana Ronai, Fei Li Kuang, Jonathan U. Peled, Maria D. Iglesias-Ussel et al.
    Pages 93-109
  10. Zhenming Xu, Hong Zan, Zsuzsanna Pal, Paolo Casali
    Pages 111-127
  11. Uttiya Basu, Jayanta Chaudhuri, Ryan T. Phan, Abhishek Datta, Frederick W. Alt
    Pages 129-137
  12. David M. Mills, John C. Stolpa, John C. Cambier
    Pages 139-148
  13. Yoshiteru Sasaki, Marc Schmidt-Supprian, Emmanuel Derudder, Klaus Rajewsky
    Pages 149-154
  14. GGötz R. A. Ehrhardt, Chuen-Miin Leu, Shuangyin Zhang, Güzide Aksu, Tanisha Jackson, Chris Haga et al.
    Pages 155-162
  15. Christopher C. Goodnow, James A. Campbell, Lixin Rui, Carola G. Vinuesa
    Pages 163-168
  16. José Luis Vela, David Nemazee
    Pages 169-172
  17. Mark S. Schlissel*
    Pages 173-179
  18. Christine Grimaldi, Emil Nashi, Jeganathan Venkatesh, Betty Diamond
    Pages 181-190
  19. Back Matter
    Pages 191-196

About these proceedings

Introduction

In recent years, major developments have been made in understanding various genetic and epigenetic regulatory processes that are critical for the generation of B cell repertoires. These include the role of chromatin regulation and nuclear organization in understating the IgH gene regulation. A role and mechanism of DNA repair proteins in somatic hypermutation has been elucidated. Genetic mutation studies have been instrumental in providing insight into some of the mechanisms involved in targeting CSR to various switch DNA regions located upstream of C region genes, especially a role of AID motifs, transcription, and R-loops. Recent studies support a dominant role of receptor editing in central B cell tolerance and signaling pathways that regulate receptor editing in self-reactive and non-self-reactive immature B cells. These were some of the topics of discussion at the 11th International Conference on B cell Biology. These proceedings highlight recent developments in lymphocyte development, Ig gene rearrangements and somatic hypermutation, chromatin structure modification, B lymphocyte signaling and fate, receptor editing, and autoimmunity.

Keywords

autoimmunity biomedicine immunology lymphocyte protein

Editors and affiliations

  • Sudhir Gupta
    • 1
  • Frederick Alt
    • 2
  • Max Cooper
    • 3
  • Fritz Melchers
    • 4
  • Klaus Rajewsky
    • 5
  1. 1.School of Medicine, College of Health SciencesUniversity of CaliforniaIrvineUSA
  2. 2.Department of GeneticsChildren's Hospital BostonBostonUSA
  3. 3.Inst. Medical/Tumor Research LaboratoriesUniversity of AlabamaBirminghamUSA
  4. 4.BiozentrumAbt. ZellbiologieMax Planck Institute for Infection BiologyBerlin, 4056Germany
  5. 5.Center for Blood ResearchHarvard Medical SchoolBostonUSA

Bibliographic information

  • Copyright Information Springer Science+Business Media, LLC 2007
  • Publisher Name Springer, Boston, MA
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-0-387-46527-2
  • Online ISBN 978-0-387-46530-2
  • Series Print ISSN 0065-2598