Current Topics in Complement

  • John D. Lambris
Conference proceedings

DOI: 10.1007/0-387-34134-X

Part of the Advances in Experimental Medicine and Biology book series (volume 586)

Table of contents

  1. Front Matter
    Pages i-xxii
  2. Robert A. DeAngelis, Maciej M. Markiewski, John D. Lambris
    Pages 17-34
  3. Ryan Reca, Marcin Wysoczynski, Jun Yan, John D. Lambris, Mariusz Z. Ratajczak
    Pages 35-51
  4. Purushottam Jha, Puran S. Bora, Jeong-Hyeon Sohn, Henry J. Kaplan, Nalini S. Bora
    Pages 53-62
  5. Panagiotis A. Tsonis, John D. Lambris, Katia Del Rio-Tsonis
    Pages 63-70
  6. Berhane Ghebrehiwet, Claudia CebadaMora, Lee Tantral, Jolyon Jesty, Ellinor I. B. Peerschke
    Pages 95-105
  7. Miki Nakao, Yoko Kato-Unoki, Makiko Nakahara, Junichi Mutsuro, Tomonori Somamoto
    Pages 121-138
  8. J Mocco, Michael E. Sughrue, Andrew F. Ducruet, Ricardo J. Komotar, Sergei A. Sosunov, E. Sander Connolly Jr.
    Pages 189-201
  9. Heike Schreiber, Daniel Rittirsch, Michael Flierl, Uwe Brueckner, Marion Schneider, Manfred Weiss et al.
    Pages 217-226
  10. Yuichi Endo, Yu Liu, Teizo Fujita
    Pages 265-279
  11. Lieve Nuytinck, Els De Meester, Martine Van Thielen, Paul Govaerts
    Pages 281-290

About these proceedings

Introduction

Complement has long been regarded as a pivotal effector arm of the innate im-mune response, eliciting important immunoregulatory functions in the context of inflammation and also serving as a vital link between the innate and adaptive immune response. In the post-genomic era, our knowledge of the innate immune system is enriched by findings that point to novel functions that do not strictly correlate with immunological defense and surveillance, immune modulation or inflammation. Several studies indicate that complement proteins exert functions that are either more complex than previously thought, or go well beyond the innate immune character of the system. The advent of high-throughput platforms for genome and proteome-wide profiling, together with the enormous amount of raw genetic information that has accumulated in the databases, have stirred new expectations in biomedical research. They have led complementologists to revisit established biological systems, such as the complement system, from a global and integrative perspec-tive. Complement research is now faced with the challenge of trying to integrate isolated biochemical pathways into complex gene and protein regulatory cir-cuits. In this respect, scientists from around the world convened at the Third Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics (June 5–10, 2005), to discuss recent advances in this fast evolving field. This volume represents a collection of topics on the "novel" functions of complement, pathophysiology, protein structures, design of complement inhibitors, and complement assays discussed during the conference.

Keywords

Sepsis bone marrow cancer diseases neuroinflammation pathogenesis pathophysiology pharmacology physiology protein proteins

Editors and affiliations

  • John D. Lambris
    • 1
  1. 1.University of PennsylvaniaPhiladelphia

Bibliographic information

  • Copyright Information Springer Science+Business Media, LLC 2006
  • Publisher Name Springer, Boston, MA
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-0-387-32231-5
  • Online ISBN 978-0-387-34134-7
  • Series Print ISSN 0065-2598