Dipeptidyl Aminopeptidases

Basic Science and Clinical Applications

Editors:

ISBN: 978-0-387-29058-4 (Print) 978-0-387-32824-9 (Online)

Table of contents (25 chapters)

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  1. Structure and Function

    1. Front Matter

      Pages 1-1

    2. No Access

      Book Chapter

      Pages 3-18

      Peptide Substrates of Dipeptidyl Peptidases

    3. No Access

      Book Chapter

      Pages 19-26

      Phosphorus-Containing Inhibitors of Proteolytic Enzymes

    4. No Access

      Book Chapter

      Pages 27-32

      Biochemical Properties of Recombinant Prolyl Dipeptidases DPP-IV and DPP8

    5. No Access

      Book Chapter

      Pages 33-42

      Prediction of Dipeptidyl Peptidase (DP) 8 Structure by Homology Modelling

  2. Dpiv-Related Enzymes

    1. Front Matter

      Pages 43-43

    2. No Access

      Book Chapter

      Pages 45-54

      Structure and Function in Dipeptidyl Peptidase IV and Related Proteins

    3. No Access

      Book Chapter

      Pages 55-62

      Expression and Function of Dipeptidyl Peptidase IV and Related Enzymes in Cancer

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      Book Chapter

      Pages 63-72

      DP8 and DP9 have Extra-Enzymatic Roles in Cell Adhesion, Migration and Apoptosis

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      Book Chapter

      Pages 73-85

      In Vivo Effects of a Potent, Selective Dppii Inhibitor

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      Book Chapter

      Pages 87-91

      Expression of Dipeptidyl Peptidase IV-Like Enzymes in Human Peripheral Blood Mononuclear Cells

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      Book Chapter

      Pages 93-102

      Dipeptidyl Peptidase 8 Has Post-Proline Dipeptidyl Aminopeptidase and Prolyl Endopeptidase Activities

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      Book Chapter

      Pages 103-108

      Prolyl Endopeptidase Cleaves the Apoptosis Rescue Peptide Humanin and Exhibits an Unknown Post-Cysteine Cleavage Specificity

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      Book Chapter

      Pages 109-116

      Distribution of Dipeptidyl Peptidase Iv-Like Activity Enzymes in Canine and Porcine Tissue Sections by RT-PCR

  3. Metabolic Disorders

    1. Front Matter

      Pages 117-117

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      Book Chapter

      Pages 119-133

      Relative Contribution of Incretins to the Glucose Lowering Effect of DP IV Inhibitors in Type 2 Diabetes Mellitus (T2DM)

    3. No Access

      Book Chapter

      Pages 135-140

      Dipeptidyl Peptidase IV: A Molecular Switch of Vascular Actions of Neuropeptide Y

  4. Immune Disorders

    1. Front Matter

      Pages 141-141

    2. No Access

      Book Chapter

      Pages 143-153

      Dipeptidylpeptidase IV (DPIV) and Alanyl-Aminopeptidases (AAPs) as a New Target Complex for Treatment of Autoimmune and Inflammatory Diseases—Proof of Concept in a Mouse Model of Colitis

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      Book Chapter

      Pages 155-162

      Dipeptidyl Peptidases and Inflammatory Bowel Disease

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      Book Chapter

      Pages 163-167

      Possible Role of DP IV Inhibitors in Acne Therapy

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      Book Chapter

      Pages 169-174

      Dipeptidyl Peptidase-IV Activity and/or Structure Homologs (DASH): Contributing Factors in the Pathogenesis of Rheumatic Diseases?

  5. Neuronal Diseases

    1. Front Matter

      Pages 175-175

    2. No Access

      Book Chapter

      Pages 177-186

      Dipeptidyl Peptidase IV (DP IV, CD26) and Aminopeptidase N (APN, CD13) as Regulators of T Cell Function and Targets of Immunotherapy in CNS Inflammation

    3. No Access

      Book Chapter

      Pages 187-193

      CD26/DP IV in T Cell Activation and Autoimmunity

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