2006

The Proteasome in Neurodegeneration

Editors:

ISBN: 978-0-387-28499-6 (Print) 978-0-387-28500-9 (Online)

Table of contents (18 chapters)

  1. Basic Aspects of Protein Degradation Through the Ubiquitin Proteasome System (UPS)

    1. No Access

      Book Chapter

      Pages 1-16

      Yeast Proteasome Structure and Biogenesis

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      Book Chapter

      Pages 17-37

      Ubiquitin-Proteasome System in the Central Nervous System

  2. Protein Aggregation, Inclusion Formation and Ups Function

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      Book Chapter

      Pages 39-55

      Protein Aggregation and the UPS: A Two-Way Street

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      Book Chapter

      Pages 57-67

      The Impact of Inclusion Formation on Cell Survival

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      Book Chapter

      Pages 69-84

      Inclusion Formation and Disolution Following Proteasomal Inhibition in Neuronal Cells

  3. Oxidative Stress and Ups Function

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      Book Chapter

      Pages 85-103

      The Proteasome: Source and a Target of Oxidative Stress?

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      Book Chapter

      Pages 105-131

      Inflammation as a Mediator of Oxidative Stress and UPS Dysfunction

  4. Proteasome and Neuronal Cell Death and Survival

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      Book Chapter

      Pages 133-148

      Role of the Ubiquitin Proteasome System During Neuronal Cell Death

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      Book Chapter

      Pages 149-165

      Pathways of Neuronal Cell Death Induced by Proteasomal Inhibition

  5. Models of Dysfunction of the UPS and the Proteasome

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      Book Chapter

      Pages 167-183

      Pharmacological and Molecular Models of Proteasomal Dysfunction

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      Book Chapter

      Pages 185-198

      The Gad Mouse: A Window Into UPS-Related Neurodegeneration and the Function of the Function of the Deubiquitinating Enzyme Uch-L1

  6. The UPS in Neurodegenerative Diseases and Aging

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      Book Chapter

      Pages 199-212

      Parkinson’s Disease and Related Disorders

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      Book Chapter

      Pages 213-224

      Ubiquitination by Parkin — Implications in Parkinson’s Disease

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      Book Chapter

      Pages 225-235

      The Ups in Neurodegenerative Diseases and Aging Huntington’s Disease

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      Book Chapter

      Pages 237-246

      Frameshift Mutant Ubiquitin in Alzheimer’s Disease and Other Neurodegenerative Disorders

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      Book Chapter

      Pages 247-264

      Motor Neuron Disease

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      Book Chapter

      Pages 265-283

      The Paradoxical Role of Proteasomes in Prion Disorders

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      Book Chapter

      Pages 285-298

      Aging and the Proteasome