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The Link Between Inflammation and Cancer

Wounds that do not heal

  • Book
  • © 2006

Overview

Editors:
  1. Angus G. Dalgleish

    1. Division of Oncology, St. George’s Hospital Medical School, London, UK

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  2. Burkhard Haefner

    1. Department of Oncology Johnson and Johnson Pharmaceutical, Research and Development, Beerse, Belgium

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    You can also search for this editor in PubMed   Google Scholar

  • The focus is on NF-kB as a crucial regulator of inflammatory response, driver of tumorigenesis in many types of cancer and key drug target
  • Provides cross-disciplinary approach (cancer/inflammation research) promoting a more holistic understanding (thinking outside of the box) of the complex process of tumorigenesis
  • Includes supplementary material: sn.pub/extras

Part of the book series: Cancer Treatment and Research (CTAR, volume 130)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xii
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  2. Inflammation and Cancer

    • Angus G. Dalgleish, Ken O’Byrne
    Pages 1-38

  3. Chronic Inflammation and Pathogenesis of GI and Pancreatic Cancers

    • Lindsey Jackson, B. Mark Evers
    Pages 39-65

  4. Cytokines, NF-κB, Microenvironment, Intestinal Inflammation and Cancer

    • Arndt J. Schottelius, Harald Dinter
    Pages 67-87

  5. Regulation if NF-κB Transcriptional Activity

    • Linda Vermeulen, Wim Vanden Berghe, Guy Haegeman
    Pages 89-102

  6. The Role of Immune Cells in the Tumor Microenvironment

    • Theresa L. Whiteside
    Pages 103-124

  7. Tumor-Microenvironment Interactions

    • Isaac P. Witz
    Pages 125-140

  8. CD95L/FasL and TRAIL in Tumour Surveillance and Cancer Therapy

    • Harald Wajant
    Pages 141-165

  9. Infection & Neoplastic Growth 101

    • Jessica Bertout, Andrei Thomas-Tikhonenko
    Pages 167-197

  10. Cytokines as Mediators and Targets for Cancer Cachexia

    • Josep M. Argilés, Sílvia Busquets, Francisco J. López-Soriano
    Pages 199-217

  11. Targeting NF-κB in Anticancer Adjunctive Chemotherapy

    • Burkhard Haefner
    Pages 219-245

  12. Back Matter

    Pages 247-254
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Keywords

About this book

A link between inflammation and cancer has been established many years ago, yet it is only recently that the potential significance of this connection has become apparent. Although several examples of chronic inflammatory conditions, often induced by persistent irritation and/or infection, developing into cancer have been known for some time, there has been a notable resistance to contemplate the possibility that this association may apply in a causative way to other cancers. Examples for such progression from chronic inflammation to cancer are colon carcinoma developing with increased frequency in patients with ulcerative colitis, and the increased incidence of bladder cancer in patients suffering from chronic Schistosoma infection. Inflammation and cancer have been recognized to be linked in another context for many years, i.e., with regards to pathologies resembling chronic lacerations or 'wounds that do not heal.' More recently, the immunology of wound healing has given us clues as to the mechanistic link between inflammation and cancer, in as much as wounds and chronic inflammation turn off local cell-mediated immune responses and switch on growth factor release as well the growth of new blood vessels - angiogenesis. Both of these are features of most types of tumours, which suggest that tumours may require an immunologically shielded milieu and a growth factor-rich environment.

Editors and Affiliations

  • Division of Oncology, St. George’s Hospital Medical School, London, UK

    Angus G. Dalgleish

  • Department of Oncology Johnson and Johnson Pharmaceutical, Research and Development, Beerse, Belgium

    Burkhard Haefner

Bibliographic Information

  • Book Title: The Link Between Inflammation and Cancer

  • Book Subtitle: Wounds that do not heal

  • Editors: Angus G. Dalgleish, Burkhard Haefner

  • Series Title: Cancer Treatment and Research

  • DOI: https://doi.org/10.1007/b137303

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag US 2006

  • Hardcover ISBN: 978-0-387-26282-6Published: 21 November 2005

  • Softcover ISBN: 978-1-4419-3881-7Published: 08 December 2010

  • eBook ISBN: 978-0-387-26283-3Published: 05 March 2006

  • Series ISSN: 0927-3042

  • Series E-ISSN: 2509-8497

  • Edition Number: 1

  • Number of Pages: XII, 254

  • Topics: Oncology, Cancer Research, Laboratory Medicine

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