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  • Book
  • © 2005

Experimental Models of Multiple Sclerosis

  • This is the only title on experimental models of multiple sclerosis

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Table of contents (51 chapters)

  1. Front Matter

    Pages i-xii
  2. Experimental Allergic (Autoimmune) Encephalomyelitis (EAE)

    1. Front Matter

      Pages xiii-xiii
    2. Induction of EAE

      • Eli Ben-Chetrit, Stefan Brocke
      Pages 11-24
    3. Histopathology of EAE

      • Michael J. Day
      Pages 25-43
    4. Neuroantigens in EAE

      • James Garbern
      Pages 45-72
    5. Adjuvants in EAE

      • Cris S Constantinescu, Brendan A Hilliard
      Pages 73-84
    6. Role of Microglia and Macrophages in Eae

      • Gennadij Raivich, Richard Banati
      Pages 109-131
    7. The Neuron and Axon in Experimental Autoimmune Encephalomyelitis

      • Nikos Evangelou, Cris S Constantinescu
      Pages 133-149
    8. T Lymphocytes in EAE

      • Kelli Ryan, Stephen M Anderton
      Pages 201-243
    9. The Role of Complement in EAE

      • Johan van Beek, B. Paul Morgan
      Pages 245-267
    10. B Cells and Antibodies in Experimental Autoimmune Encephalomyelitis

      • Xia Lin, Cris S Constantinescu
      Pages 269-281
    11. Cytokines in Experimental Autoimmune Encephalomyelitis

      • Cris S Constantinescu, David Baker
      Pages 283-311
    12. The Role of Interferons in Experimental Autoimmune Encephalomyelitis

      • Hubertine Heremans, Alfons Billiau
      Pages 313-342
    13. The Role of Growth Factors in Experimental Autoimmune Encephalomyelitis

      • Amy E. Lovett-Racke, Michael K. Racke
      Pages 343-361
    14. The Chemokine System in Experimental Autoimmune Encephalomyelitis

      • Andrzej R Glabinski, Richard M. Ransohoff
      Pages 363-377

About this book

Multiple Sclerosis (MS) is an enigmatic immune mediated disease of the central nervous system that affects about 350,000 individuals in the US, and many more around the world. The mechanism of this disease is largely unknown and there is no cure for it. However, there are several well-characterized experimental animal models that help us understand and speculate about potential mechanisms of pathology in this disease. Many of the experimental therapies designed for this disease rely on testing the drugs in animal models before using it in clinical trials. This book combines for the first time the different experimental models for MS (including immune-mediated and viral) under one roof, and highlights aspects that are different or shared among these experimental models. It’s aim is to improve our understanding of this devastating disease and help us think about potential additional therapies for it.

Reviews

From the reviews:

"A specialist book that aims to combine and present information about every existing animal model for multiple sclerosis. The target audience for this book includes neuroscientists, neurologists, immunologists, microbiologists, and neuropathologists. Clearly, some neuroradiologists … will also benefit from the information in this book. For the readers of AJNR, it is thought that a primary use of this book might be a reference for those collaborating with basic neuroscientists. … This will be a valuable resource for any scientists … ." (American Journal of Neuroradiology, January, 2007)

Editors and Affiliations

  • Weill Medical College of Cornell University, New York

    Ehud Lavi

  • Queen’s Medical Centre, University Hospital, Nottingham, UK

    Cris S. Constantinescu

Bibliographic Information

Buy it now

Buying options

eBook USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access