Overview
- Offers comprehensive, up-to-date coverage of a broad range of pediatric tumors
- Discusses Neuroblastoma, Medulloblastoma, Leukemia, Lymphoma, Rhabdoid, Sarcoma and Miscellaneous Tumors
- Features the work of 91 experts - oncologists, neurosurgeons, physicians, research scientists and pathologists - representing 13 countries
Part of the book series: Pediatric Cancer (PECA, volume 4)
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Table of contents (33 chapters)
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Front Matter
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Neuroblastoma
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Front Matter
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Leukemia
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Front Matter
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Lymphoma
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Front Matter
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Keywords
About this book
This entry in the series Pediatric Cancer offers comprehensive information on a variety of cancers, concentrating on brain tumors, the most common solid tumors and the leading cause of cancer-related mortality in children. The contents are organized in seven sections: Neuroblastoma, Medulloblastoma, Leukemia, Lymphoma, Rhabdoid, Sarcoma and Miscellaneous Tumors.
Coverage includes pediatric medulloblastoma, and treatments including craniospinal radiation followed by adjuvant chemotherapy. The contributors explain diagnosis and chemotherapy of children with acute lymphoblastic leukemia, and diagnosis of bone marrow involvement in pediatric lymphoma patients. Ewing’s sarcoma, a highly malignant connective tissue neoplasm formed by the proliferation of mesenchymal cells, receives extensive coverage, including targeting of molecular pathways and chemotherapy and surgical treatment. The roles of apoptotic genes, MYCN gene, MDM2, and SNP309, P13K inhibitors, alternative splicing and microRNAs, activated leukocyte cell adhesion molecule and inhibition by alu-like RNA in neuroblastoma are discussed in detail.
The book explores the molecular genetics, diagnosis, prognosis and therapy of the atypical teratoid/rhabdoid tumor (AT/RT). Among the most common malignant neoplasms in children, AT/RT exhibits similarities with other CNS tumors, which can lead to misclassification, as pointed out in the book. The contributors discuss diagnosis of AT/RT type using imaging technology, and describe new strategies, including intensive multimodal therapy and high dose chemotherapy with autologous stem cell transplantation that have shown improved outcomes. Coverage of therapies includes total resection followed by aggressive chemotherapy and radiation.
Discussion includes diagnosis and treatment of other pediatric tumors including adrenocorticaltumors, supratentorial primitive neuroectodermal tumors, giant midline tumors, gastrointestinal stromal tumors, ependymomas and intramedullary cavernoma.
Pediatric Cancer: Diagnosis, Therapy and Prognosis, Volume 4 includes contributions by ninety-one contributors - oncologists, neurosurgeons, physicians, research scientists and pathologists - representing thirteen countries.
The editor, M.A. Hayat, is a Distinguished Professor in the Department of Biological Sciences at Kean University, Union, New Jersey, USA.
Editors and Affiliations
Bibliographic Information
Book Title: Pediatric Cancer, Volume 4
Book Subtitle: Diagnosis, Therapy, and Prognosis
Editors: M.A. Hayat
Series Title: Pediatric Cancer
DOI: https://doi.org/10.1007/978-94-007-6591-7
Publisher: Springer Dordrecht
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media Dordrecht 2013
Hardcover ISBN: 978-94-007-6590-0Published: 14 June 2013
Softcover ISBN: 978-94-024-0726-6Published: 23 August 2016
eBook ISBN: 978-94-007-6591-7Published: 29 May 2013
Series ISSN: 2211-7997
Series E-ISSN: 2211-8004
Edition Number: 1
Number of Pages: XXXVI, 346
Number of Illustrations: 23 b/w illustrations, 32 illustrations in colour
Topics: Cancer Research, Biomedicine general, Medicine/Public Health, general, Entomology