Non-Disseminated Breast Cancer

1. Front Matter

   Pages I-XIV

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2. Is Breast Cancer Curable?

   • Gilbert H. Fletcher

   Pages 1-3

3. Criteria of Operability in Advanced Breast Cancer

   • Walter Lawrence Jr., Gilbert H. Fletcher

   Pages 5-9

4. Postoperative Radiotherapy and the Pattern of Distant Spread in Breast Cancer

   • Maurice Tubiana

   Pages 11-26

5. How Much of the Axilla Should Be Dissected?

   • Robert T. Osteen

   Pages 27-34

6. How Much of the Effect of Chemotherapy Is Due to Hormonal Manipulation?

   • Nigel P. M. Sacks, Roger P. A’Hern, Michael Baum

   Pages 35-42

7. Chemotherapy for Node-Negative Breast Cancer

   • Richard J. Epstein, I. Craig Henderson

   Pages 43-56

8. Treatment of the Peripheral Lymphatics: Rationale, Indications, and Techniques

   • Eric A. Strom, Marsha D. McNeese, Gilbert H. Fletcher

   Pages 57-72

9. What Is the Value of Clinical Trials?

   • Seymour H. Levitt, Lars-Erik Rutqvist

   Pages 73-81

10. What Have We Learned from the Stockholm Trials on Adjuvant Radiation Therapy in Early-Stage Breast Cancer?

    • Lars-Erik Rutqvist

    Pages 83-92

11. Pathologic Factors Predictive of Local Recurrence in Patients with Invasive Breast Cancer Treated by Conservative Surgery and Radiation Therapy

    • Stuart J. Schnitt

    Pages 93-104

12. What Is the Optimal Technique of Irradiation in Breast-Conserving Treatment?

    • Tatiana I. Lingos, Jay R. Harris

    Pages 105-115

13. Which Patients Should Be Treated by Breast Conservation Surgery and Which by Modified Radical Mastectomy

    • Timothy J. Eberlein, Linda M. Douville

    Pages 117-128

14. What Is the Role of Adjuvant Chemotherapy in Postmenopausal Women with Operable Breast Cancer?

    • James N. Ingle

    Pages 129-142

15. How Should We Treat Ductal Carcinoma In Situ?

    • Abram Recht

    Pages 143-154

16. How Successful Is Breast Reconstruction?

    • Robert M. Goldwyn

    Pages 155-160

17. Back Matter

    Pages 161-168

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In the last two decades, there has been a major increase in the actual numbers of women diagnosed with breast cancer (from 65000 new cases 20 years ago in the United States to 183000 in 1993). Concomitant with this has been a shift toward making the diagnosis earlier and toward diagnosing an earlier stage ofthe disease (more than 70% of diagnoses were of advanced-stage disease two decades ago, whereas more than 70% of diagnoses are now earlier-stage disease in 1992). These changes are clearly related to the woman's greater sensitivity to abnormalities in the breast and her seeking medical care, to the physician's greater awareness of the potential diagnosis of cancer, and to the major and important impact of mammographic screening. These changes have had a major impact on the questions of appropriate treatment, thereby contributing to the controversies in the disease. What is the role of surgery? What are the respective advantages of radical mastectomy, modified radical mastectomy, and conservation surgery with and without supplementary treatment? What is the role of radiation therapy? When should radiation therapy be performed after mastectomy, and what volumes should be irradiated post mastectomy? Where is radiation therapy indicated after conservation surgery, and when is radiation therapy an effective palliative treatment measure? When should chemotherapy and/or hormonal therapy be used as an adjuvant to primary treatment and when as an effective palliative treatment? This book by Levitt and Fletcher addresses these critical and important issues.

• Brustkrebs
• Onkologie
• breast cancer
• cancer
• carcinoma
• chemotherapy
• clinical trial
• nondiseminated breast cancer
• oncology
• pathology
• radiation
• radiation therapy
• radiology
• radiotherapy
• surgery
• Radiaton Oncology

• Department of Radiotherapy, M.D. Anderson Cancer Center, Houston, USA

  Gilbert H. Fletcher

• Department of Therapeutic Radiology - Radiation Oncology, University of Minnesota, Minneapolis, USA

  Seymour H. Levitt

Policies and ethics