Reproductive Immunology

1. Front Matter

   Pages I-XI

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2. Immunogenetics of Reproduction:An Overview

   • C. Ober, K. van der Ven

   Pages 1-23

3. The Structural Basis of Maternal-Fetal Immune Interactions in the Human Placenta

   • R. W. Redline

   Pages 25-44

4. Immunobiology of the Decidua

   • P. C. Arck, D. A. Clark

   Pages 45-66

5. Ontogeny of Human Natural and Acquired Immunity

   • M. Adinolfi

   Pages 67-102

6. Maternal T Cell Reactivity in Pregnancy?

   • G. Chaouat, E. Menu

   Pages 103-126

7. Immunobiology of the Trophoblast:Mechanisms by Which Placental Tissues Evade Maternal Recognition and Rejection

   • D. S. Torry, J. A. Mcintyre, W. P. Faulk

   Pages 127-140

8. Traffic of Leukocytes Through the Maternofetal Placental Interface and Its Possible Consequences

   • N. Papadogiannakis

   Pages 141-157

9. Suppressive Cellular and Molecular Activities in Maternofetal Immune Interactions; Suppressor Cell Activity, Prostaglandins, and Alpha-Fetoproteins

   • L. B. Olding, N. Papadogiannakis, B. Barbieri, R. A. Murgita

   Pages 159-187

10. The Immunopathology of Recurrent Abortion

    • A. M. Unander

    Pages 189-203

11. Transfer of Maternal Leukocytes to the Infant by Human Milk

    • A. S. Goldman, R. M. Goldblum

    Pages 205-213

12. Back Matter

    Pages 215-223

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Discrimination of self from nonself is the major function of the immune system and understanding the mechanism(s) involved a main employer of immunologists. Hence, the age-old puzzle of why a fetus that contains a panel of major histocompatibility (MHC) antigens derived from its mother and its father is not rejected (spontaneously aborted) by lymphocytes from its mother who should theoretically recognize foreign MHC molecules from the father has remained of great interest. This dilemma has enticed immunologists and developmental biologists for many years. This volume was created to present the information currently on hand in this subject to the scientific public. The guest editor, Professor Lars Olding, has a long and distinguished history of contributions in this field, having been one of the main propo­ nents of the argument that lymphocytes from the fetus play an active role in this process by suppressing lymphocytes from the mother from proliferating and thereby acting as killer cells. His work has defined the phenomenon and identified suppressor molecules (factors) involved in the process. In a different but related chapter, Margareta Unander extends such observations to the clinical study of women with repeated "habitual" mIS­ carriages.

• Antigen
• Fortpflanzung
• Immunität
• fetus
• genetics
• immunity
• lymphocytes
• placenta
• plazenta
• pregnancy
• reproduction

"...a dense synthesis of current knowledge of the fetomaternal interactions, contains the most recent scientific achievements, and reveals the controversial issues."
Immunology Today

• Department of Immunology, Microbiology, Pathology and Infectious Diseases Karolinska Institute Division of Pathology, F42 Huddinge University Hospital, Huddinge, Sweden

  Lars B. Olding

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