Chemistry and Biological Actions of 4-Nitroquinoline 1-Oxide

1. Front Matter

   Pages i-xii

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2. Introduction

   • Takashi Sugimura

   Pages 1-2

3. Chemical Properties

   • Yutaka Kawazoe

   Pages 3-16

4. Biophysics

   • Chikayoshi Nagata

   Pages 17-31

5. Carcinogenicity

   • Hideya Endo

   Pages 32-52

6. Metabolism

   • Taijiro Matsushima, Takashi Sugimura

   Pages 53-60

7. Molecular Aspects of the Action

   • Hideya Endo, Tetsuo Ono, Hiroto Naora

   Pages 61-65

8. Anti-tumor Effect

   • Fumiko Fukuoka

   Pages 66-73

9. Microbiology

   • Takashi Mita

   Pages 74-84

10. Back Matter

    Pages 85-103

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During the last decade a considerable body of knowledge has come into existence concerning a class of carcinogenic molecules chiefly represented by 4-nitroquinoline i-oxide. Original papers on this subject are numerous and widely scattered over many branches of science; it was felt that these papers should be reviewed and the knowledge brought together in one volume before it became too unwieldy. This we have attempted to do in this monograph. Our aim has been to include all relevant papers published to date, so that it may serve as an epitome of the present status of knowledge on this important subject. We have been fortunate in securing the cooperation of several colleagues who have contributed chapters, each dealing with one aspect of the subject. We have been doubly fortunate in that these contributors, like ourselves, were at one time or another members of the group belonging to the scientific staff of Dr. WARO NAKA­ HARA, Director of the National Cancer Center Research Institute, Tokyo, Japan.

• cancer
• chemistry
• molecule

• Department of Chemistry, Cancer Research Institute Kyushu University, Fukuoka, Japan

  Hideya Endo

• Department of Chemistry, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan

  Tetsuo Ono

• Biochemistry Division, National Cancer Center Research Institute, Tokyo, Japan

  Takashi Sugimura

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