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Chemosensitivity Testing in Oncology

  • Conference proceedings
  • © 2003

Overview

Editors:
  1. Uwe Reinhold

    1. Hautklinik und Poliklinik, Universitätskliniken des Saarlandes, Homburg/Saar, Germany

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  2. Wolfgang Tilgen

    1. Hautklinik und Poliklinik, Universitätskliniken des Saarlandes, Homburg/Saar, Germany

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Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 161)

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Table of contents (18 papers)

  1. Front Matter

    Pages I-X
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  2. In Vitro Drug Testing Methods: Recent Developments

    1. Front Matter

      Pages 1-1
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    2. Luminescence Applications for Chemotherapeutic Drug Development

      • Peter E. Andreotti, Gisela Caceres, Ralitza Zamkina, Michael Dauphinée
      Pages 3-12

    3. The Use of the MTT Assay to Study Drug Resistance in Fresh Tumour Samples

      • Jean M. Sargent
      Pages 13-25

    4. Chemosensitivity Testing of Human Tumors Using Si-sensor Chips

      • Pedro Mestres-Ventura
      Pages 26-38

    5. Multiparametric Sensor Chips for Chemosensitivity Testing of Sensitive and Resistant Tumor Cells

      • Angela M. Otto, Martin Brischwein, Helmut Grothe, Elena Motrescu, Bernhard Wolf
      Pages 39-47

    6. Development of a New In Vitro Chemosensitivity Test Using Collagen Gel Droplet Embedded Culture and Image Analysis for Clinical Usefulness

      • Hisayuki Kobayashi
      Pages 48-61

    7. In Vitro Chemosensitivity Testing of Hematological Cancer Patients: Detection of Ornithine Decarboxylase

      • Uriel Bachrach, Yongchun Wang
      Pages 62-70

  3. Tumor Chemosensitivity Assays: Evaluation of In Vitro Results

    1. Front Matter

      Pages 71-71
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    2. The Chemosensitivity Profile of Retinoblastoma

      • Federica Di Nicolantonio, Michael Neale, Zerrin Onadim, John L. Hungerford, Judith L. Kingston, Ian A. Cree
      Pages 73-80

    3. Chemosensitivity Testing in Malignant Melanoma

      • Selma Ugurel, Wolfgang Tilgen, Uwe Reinhold
      Pages 81-92

    4. Human Melanoma: Drug Resistance

      • Heike Helmbach, Pranav Sinha, Dirk Schadendorf
      Pages 93-110

    5. Cisplatin, Doxorubicin and Paclitaxel Induce mdr1 Gene Transcription in Ovarian Cancer Cell Lines

      • Thomas Schöndorf, Rainer Neumann, Carolin Benz, Martina Becker, Marion Riffelmann, Uwe-Jochen Göhring et al.
      Pages 111-116

  4. Clinical Relevance of Tumor-Directed Therapy

    1. Front Matter

      Pages 117-117
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    2. Chemosensitivity Testing as an Aid to Anti-Cancer Drug and Regimen Development

      • Ian A. Cree
      Pages 119-125

    3. Assay-Assisted Treatment Selection for Women with Breast or Ovarian Cancer

      • John P. Fruehauf, David S. Alberts
      Pages 126-145

    4. Chemosensitivity Testing in Gynecologic Oncology — Dream or Reality?

      • M. Untch, N. Ditsch, E. Langer, C. Kurbacher, C. Crohns, G. Konecny et al.
      Pages 146-158

    5. Treosulfan in the Treatment of Metastatic Melanoma: From Chemosensitivity Testing to Clinical Trials

      • Karsten Neuber
      Pages 159-179

    6. Chemosensitivity Testing and Test-Directed Chemotherapy in Human Pancreatic Cancer

      • Marko Kornmann, Hans G. Beger, Karl H. Link
      Pages 180-195

    7. Clinical Significance of Cellular Drug Resistance in Childhood Leukemia

      • G. J. L. Kaspers, A. J. P. Veerman
      Pages 196-220
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Keywords

About this book

Over the past 50 years many in vitro and in vivo drug response assay systems have been developed to determine the potential - tivity of chemotherapy agents. The idea was to eliminate ineffective agents and unnecessary toxic treatment while selecting drugs active in vitro or in the mouse model that might increase the probability of response in the patient. None of these test models, however, achieved routine clinical application in the past. This might be at least in part - lated to large discrepancies that were described between the s- cess rate of the assay systems and the clinical benefit in cancer - tients. The heterogeneity of chemosensitivity that exists between different tumors as well as between individual tumor lesions may be one explanation for these findings. Furthermore, different assay end points such as proliferation, metabolism, and vitality were - veloped to evaluate the effects of cytostatic drugs on tumor cells, and these might be related to the differing results. However, knowledge about procedures for assay-assisted treatment selection has increased rapidly within the past few years, and several studies suggest that test-directed chemotherapy selection now may - prove response rates and survival in various types of tumors. The International Society for Chemosensitivity Testing in - cology (ISCO) was founded to promote, coordinate, and improve clinical and laboratory research in the field of predictive drug te- ing in human tumor cells.

Editors and Affiliations

  • Hautklinik und Poliklinik, Universitätskliniken des Saarlandes, Homburg/Saar, Germany

    Uwe Reinhold, Wolfgang Tilgen

Bibliographic Information

  • Book Title: Chemosensitivity Testing in Oncology

  • Editors: Uwe Reinhold, Wolfgang Tilgen

  • Series Title: Recent Results in Cancer Research

  • DOI: https://doi.org/10.1007/978-3-642-19022-3

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2003

  • Hardcover ISBN: 978-3-540-43468-9Published: 31 October 2002

  • Softcover ISBN: 978-3-642-62412-4Published: 08 October 2012

  • eBook ISBN: 978-3-642-19022-3Published: 06 December 2012

  • Series ISSN: 0080-0015

  • Series E-ISSN: 2197-6767

  • Edition Number: 1

  • Number of Pages: X, 245

  • Topics: Cancer Research, Oncology

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