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Tumor Angiogenesis

Basic Mechanisms and Cancer Therapy

  • Book
  • © 2008

Overview

Editors:
  1. Dieter Marmé

    1. Klinik für Tumorbiologie, Freiburg i. Br., Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Norbert Fusenig

    1. DKFZ, Heidelberg, Germany

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    You can also search for this editor in PubMed   Google Scholar

  • Written by internationally renowned experts

  • Development of novel drugs (e.g. Avastin) makes new therapeutic strategies in the treatment of cancer possible

  • Includes supplementary material: sn.pub/extras

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Table of contents (45 chapters)

  1. Front Matter

    Pages I-XVIII
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  2. Historical Overview

    1. Front Matter

      Pages 1-1
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    2. Tumor Angiogenesis: from Bench to Bedside

      • Judah Folkman
      Pages 3-28

  3. Mechanisms

    1. Front Matter

      Pages 29-29
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    2. Vasculogenesis and Angiogenesis in Development

      • Anne Eichmann, Karine Bouvrée, Luc Pardanaud
      Pages 31-45

    3. Guidance of Vascular and Neuronal Network Formation

      • Carmen Ruiz de Almodovar, Serena Zacchigna, Monica Autiero, Peter Carmeliet
      Pages 47-65

    4. The Angiogenic Switch in Tumorigenesis

      • Andreas Wicki, Gerhard Christofori
      Pages 67-88

    5. Pathophysiology and Clinical Implications of Vascular Endothelial Growth Factor

      • Napoleone Ferrara
      Pages 89-108

    6. Regulation of Angiogenesis and Vascular Homeostasis Through the Angiopoietin / Tie System

      • Hellmut G. Augustin, Ulrike Fiedler
      Pages 109-120

    7. Eph Receptors and Ephrins: Role in Vascular Development and Tumor Angiogenesis

      • Dana M. Brantley-Sieders, Jin Chen
      Pages 121-134

    8. The Role of the Neuropilins and Their Associated Plexin Receptors in Tumor Angiogenesis and Tumor Progression

      • Gera Neufeld, Ofra Kessler
      Pages 135-153

    9. Platelet-derived Growth Factor: Impact on Physiological and Tumor Angiogenesis

      • Arne Östman, Christer Betsholtz
      Pages 155-169

    10. Hypoxia and Tumour Angiogenesis

      • M. Christiane Brahimi-Horn, Julie Laferrière, Nathalie Mazure, Jacques Pouyssegur
      Pages 171-194

    11. Hypoxia and Angiogenesis in Glioblastomas

      • Till Acker, Karl H. Plate
      Pages 195-214

    12. Endogenous Inhibitors of Angiogenesis

      • Malin Sund, Raghu Kalluri
      Pages 215-231

    13. Thrombospondins and Angiogenesis

      • Nathan V. Lee, M. Luisa Iruela-Arispe
      Pages 233-245

    14. Molecular and Cellular Aspects of Heparanase

      • Neta Ilan, Liat Fux, Michael Elkin, Israel Vlodavsky
      Pages 247-272

    15. Vessel Maturation and Perivascular Cells

      • Anne M. Goodwin, PatriciaA. D’Amore
      Pages 273-288

    16. Adhesion Molecules in the Vascular Cell Cross-Talk

      • Ugo Cavallaro
      Pages 289-308

    17. Homing and Differentiation of Endothelial Progenitor Cells

      • Carmen Urbich, Emmanouil Chavakis, Stefanie Dimmeler
      Pages 309-324
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Keywords

About this book

Preface Tumor development and progression occur as a result of cumulative acquisition of genetic alterations affecting oncogenes and tumor suppressor genes. As a consequence of these alterations the arising tumor gains some fatal properties such as increased cell proliferation and decreased apoptosis, resulting in a net accumulation of tra- formed cells. Once a critical volume is achieved, lack of oxygen and nutrients limits further growth. To overcome this obstacle, the tumor cells initiate a program focused on the formation of new blood vessels within the host tissue. This process is termed tumor angiogenesis and contributes to the progression of most solid tumors and the formation of metastases. Since its discovery more than 30 years ago by Dr. Judah Folkman, tumor angiog- esis has been proposed as an ideal target for novel tumor therapies. Today the first anti-angiogenic compounds are available for the treatment of patients but their s- cess in the clinic is rather limited when given as monotherapies. This is in contrast to many preclinical results which revealed a much higher efficacy of these therapeutics in appropriate animal models. The reasons for this discrepancy are manifold, one being the existence of more than one angiogenic signaling system capable of driving tumor angiogenesis. Therefore it is no surprise that the inhibition of just one system is not sufficient to block the formation of new blood vessels in patients.

Reviews

From the reviews:

"The chapters in Tumor Angiogenesis are divided into four sections … . Tumor Angiogenesis is an outstanding overview of the basic science and translational aspects of angiogenesis. … To fully capitalize on antiangiogenic therapy, we must continue to have an open dialogue between basic scientists and clinical investigators. This book will serve that purpose, not only for graduate students and new investigators in the field, but also for experienced investigators." (Lee M. Ellis, The New England Journal of Medicine, May, 2008)

Editors and Affiliations

  • Klinik für Tumorbiologie, Freiburg i. Br., Germany

    Dieter Marmé

  • DKFZ, Heidelberg, Germany

    Norbert Fusenig

Bibliographic Information

  • Book Title: Tumor Angiogenesis

  • Book Subtitle: Basic Mechanisms and Cancer Therapy

  • Editors: Dieter Marmé, Norbert Fusenig

  • DOI: https://doi.org/10.1007/978-3-540-33177-3

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2008

  • Hardcover ISBN: 978-3-540-33176-6Published: 15 October 2007

  • Softcover ISBN: 978-3-662-51798-7Published: 23 August 2016

  • eBook ISBN: 978-3-540-33177-3Published: 05 December 2007

  • Edition Number: 1

  • Number of Pages: XVIII, 845

  • Topics: Oncology, Cancer Research, Molecular Medicine, Pharmacology/Toxicology

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